Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.

Adolescent Adult Alzheimer Disease / genetics Apolipoprotein E4 / genetics Apolipoproteins E Behavior / physiology Cognition / physiology Female Genotype Humans Male Neuropsychological Tests Sex Factors White Matter / metabolism Young Adult

APOE genotype imaging genetics sex interaction effects white matter structures young adults

Journal

Cerebral cortex (New York, N.Y. : 1991)

ISSN: 1460-2199

Titre abrégé: Cereb Cortex

Pays: United States

ID NLM: 9110718

Informations de publication

Date de publication:
01 01 2021

Historique:

received: 19 11 2019

revised: 08 08 2020

accepted: 09 08 2020

pubmed: 22 9 2020

medline: 11 1 2022

entrez: 21 9 2020

Statut: ppublish

Résumé

The APOE ɛ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex-genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.

Identifiants

DOI: 10.1093/cercor/bhaa251 PMID: 32954402 PMC: PMC7727389

pubmed: 32954402

pii: 5909022

doi: 10.1093/cercor/bhaa251

pmc: PMC7727389

doi:

Substances chimiques

ApoE protein, human 0

Apolipoprotein E4 0

Apolipoproteins E 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

672-680

Informations de copyright

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