Focus on the Multimodal Role of Autophagy in Rheumatoid Arthritis.
auto-immune
autophagy
immune response
rheumatoid arthritis
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
11
07
2020
accepted:
17
08
2020
revised:
10
08
2020
pubmed:
22
9
2020
medline:
8
10
2021
entrez:
21
9
2020
Statut:
ppublish
Résumé
Autophagy exerts its dual role in eukaryotic cells and exerts its cytoprotective action through degradation mechanism and by regulating catabolic processes which results in elimination of pathogens. Under suitable conditions, autophagy is associated with recycling of cytoplasmic components which causes regeneration of energy whereas deregulated autophagy exerts its implicated role in development and pathogenesis of auto-immune diseases such as rheumatoid arthritis. The immune, innate, and adaptive responses are regulated through the development, proliferation, and growth of lymphocytes. Such innate and adaptive responses can act as mediator of arthritis; along with this, stimulation of osteoclast-mediated bone resorption takes place via transferring citrullinated peptides towards MHC (major histocompatibility complex) compartments, thereby resulting in degradation of bone. Processes such as apoptosis resistance are also regulated through autophagy. In this review, the current knowledge based on role of autophagy in pathogenesis of rheumatoid arthritis is summarized along with proteins associated.
Identifiants
pubmed: 32954452
doi: 10.1007/s10753-020-01324-8
pii: 10.1007/s10753-020-01324-8
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-12Références
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