Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index.

The BODE (BMI, Obstruction - FEV The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TL The CADOT index has comparable prognostic power to the BODE and ADO indices. The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices. ClinicalTrials.gov (NCT01923051).