Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein.

Alzheimer Disease / metabolism Benzothiazoles / pharmacology Brain / drug effects Dementia / metabolism Humans Lewy Bodies / metabolism Parkinson Disease / metabolism alpha-Synuclein / metabolism tau Proteins / metabolism
Alpha synuclein Autoradiography and in vitro binding assay PBB3 Tissue microarrays

Journal

Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503

Informations de publication

Date de publication:
15 12 2020
Historique:
received: 29 04 2020
revised: 24 08 2020
accepted: 14 09 2020
pubmed: 22 9 2020
medline: 28 10 2021
entrez: 21 9 2020
Statut: ppublish

Résumé

The neuropathological hallmark of Parkinsońs disease, multiple system atrophy and dementia with Lewy bodies is the accumulation of α-synuclein. The development of an imaging biomarker for α-synuclein is an unmet need. To date, no selective α-synuclein imaging agent has been identified, though initial studies suggest that the tau tracer [

Identifiants

DOI: 10.1016/j.brainres.2020.147131 PMID: 32956648
pubmed: 32956648
pii: S0006-8993(20)30489-3
doi: 10.1016/j.brainres.2020.147131
pii:
doi:

Substances chimiques

Benzothiazoles 0
alpha-Synuclein 0
tau Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

147131

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Patricia Miranda-Azpiazu (P)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Electronic address: patricia.miranda.azpiazu@ki.se.

Marie Svedberg (M)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Makoto Higuchi (M)

Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Maiko Ono (M)

Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Zhisheng Jia (Z)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Dan Sunnemark (D)

Offspring Biosciences, Sweden AB, Södertälje, Sweden; Applied Immunology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Charles S Elmore (CS)

Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

Magnus Schou (M)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden; PET Science Centre, Precision Medicine, Oncology R&D, AstraZeneca, Stockholm 17176, Sweden.

Andrea Varrone (A)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Identification and in vitro characterization...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiazoles › Identification and in vitro characterization...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Identification and in vitro characterization...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Identification and in vitro characterization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification and in vitro characterization...
questionsmedicales.fr › Cellules › Structures cellulaires › Corps d'inclusion › Corps de Lewy › Identification and in vitro characterization...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Identification and in vitro characterization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Identification and in vitro characterization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Identification and in vitro characterization...