Quantifying antiviral effects against simian/human immunodeficiency virus induced by host immune response.
Parameter estimation
Population dynamics model
Simian/human immunodeficiency virus
Virus dynamics
Journal
Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342
Informations de publication
Date de publication:
21 01 2021
21 01 2021
Historique:
received:
29
06
2020
revised:
09
09
2020
accepted:
12
09
2020
pubmed:
22
9
2020
medline:
22
6
2021
entrez:
21
9
2020
Statut:
ppublish
Résumé
Chimeric simian and human immunodeficiency viruses (SHIVs) are appropriate animal models for the human immunodeficiency virus (HIV) because HIV has quite a narrow host range. Additionally, SHIVs that encode the HIV-1 Env protein and are infectious to macaques have many strains that show different pathogenesis, such as the highly pathogenic SHIV-KS661 and the less pathogenic SHIV-#64. Therefore, we used SHIVs to understand different aspects of AIDS pathogenesis. In a previous study, we established a mathematical model of in vivo early SHIV infection dynamics, which revealed the expected uninfected and infected dynamics in Rhesus macaques. In concrete, the number of uninfected CD4
Identifiants
pubmed: 32956668
pii: S0022-5193(20)30348-9
doi: 10.1016/j.jtbi.2020.110493
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110493Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.