PEG-PLGA nanospheres loaded with nanoscintillators and photosensitizers for radiation-activated photodynamic therapy.

Cell Line, Tumor Humans Nanoparticles Nanospheres Photochemotherapy Photosensitizing Agents Polyesters Polyethylene Glycols
Nanoscintillators Photodynamic therapy Prostate cancer Protoporphyrin IX RadioPDT Theranostic

Journal

Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144

Informations de publication

Date de publication:
11 2020
Historique:
received: 03 06 2020
revised: 14 09 2020
accepted: 15 09 2020
pubmed: 22 9 2020
medline: 15 5 2021
entrez: 21 9 2020
Statut: ppublish

Résumé

Photodynamic Therapy (PDT) is an effective treatment modality for cancers, with Protoporphyrin IX (PPIX)-based PDT being the most widely used to treat cancers in patients. However, PDT is limited to superficial, thin (few mm in depth) lesions that can be accessed by visible wavelength light. Interstitial light-delivery strategies have been developed to treat deep-seated lesions (i.e. prostate cancer). The most promising of these are X-ray-induced scintillation nanoparticles, which have shown potential benefits for PDT of deep-seated tumors. Herein, the design and use of a new nanoscintillator-based radiation-activated PDT (radioPDT) system is investigated in the treatment of deep-seated tumors. Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG-PLGA) nanospheres were loaded with a scintillator (LaF

Identifiants

DOI: 10.1016/j.actbio.2020.09.029 PMID: 32956872
pubmed: 32956872
pii: S1742-7061(20)30552-3
doi: 10.1016/j.actbio.2020.09.029
pii:
doi:

Substances chimiques

Photosensitizing Agents 0
Polyesters 0
polyethylene glycol-poly(lactide-co-glycolide) 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-348

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Deepak Dinakaran (D)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada. Electronic address: dinakaran@ualberta.ca.

Jayeeta Sengupta (J)

Department of Chemical and Materials Engineering, University of Alberta, 9211-116 Street NW, Edmonton, AB T6G 2G6, Canada.

Desmond Pink (D)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada; Nanostics Precision Health, Edmonton, AB, Canada.

Arun Raturi (A)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada; Entos Pharmaceuticals, Edmonton, AB. Canada.

Hua Chen (H)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada.

Nawaid Usmani (N)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada.

Piyush Kumar (P)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada.

John D Lewis (JD)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada.

Ravin Narain (R)

Department of Chemical and Materials Engineering, University of Alberta, 9211-116 Street NW, Edmonton, AB T6G 2G6, Canada. Electronic address: narain@ualberta.ca.

Ronald B Moore (RB)

Department of Oncology, University of Alberta, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada; Department of Surgery, University of Alberta, 8440 - 112 Street NW, Edmonton, AB T6G 2B7, Canada.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanosphères › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › PEG-PLGA nanospheres loaded with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › PEG-PLGA nanospheres loaded with...