Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder.

Astrocytes / metabolism Autopsy Brain / metabolism Cerebral Cortex / diagnostic imaging Depressive Disorder, Major / diagnostic imaging Female Gene Expression Profiling / methods Gene Expression Regulation / genetics Gene Ontology Gene Regulatory Networks / genetics Genome-Wide Association Study Genomics / methods Humans Interneurons / metabolism Male Multifactorial Inheritance / genetics Neuroimaging / methods Signal Transduction / genetics Single-Cell Analysis / methods Somatostatin / genetics
astrocytes gene expression major depressive disorder neuroimaging somatostatin interneurons

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
06 10 2020
Historique:
pubmed: 23 9 2020
medline: 25 11 2020
entrez: 22 9 2020
Statut: ppublish

Résumé

Major depressive disorder emerges from the complex interactions of biological systems that span genes and molecules through cells, networks, and behavior. Establishing how neurobiological processes coalesce to contribute to depression requires a multiscale approach, encompassing measures of brain structure and function as well as genetic and cell-specific transcriptional data. Here, we examine anatomical (cortical thickness) and functional (functional variability, global brain connectivity) correlates of depression and negative affect across three population-imaging datasets: UK Biobank, Brain Genomics Superstruct Project, and Enhancing NeuroImaging through Meta Analysis (ENIGMA; combined

Identifiants

DOI: 10.1073/pnas.2008004117 PMID: 32958675 PMC: PMC7547155
pubmed: 32958675
pii: 2008004117
doi: 10.1073/pnas.2008004117
pmc: PMC7547155
doi:

Substances chimiques

Somatostatin 51110-01-1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

25138-25149

Subventions

Organisme : NIMH NIH HHS
ID : K01 MH099232
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH120080
Pays : United States

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: A.M.C. holds equity in Spring Care Inc, Fitbit Inc, and UnitedHealthcare Inc. He is lead inventor on three patent submissions relating to treatment for major depressive disorder (US Patent and Trademark Office [USPTO] docket no. Y0087.70116US00, USPTO provisional application no. 62/491,660, and USPTO provisional application no. 62/629,041). He has consulted for Fortress Biotech on antidepressant drug development.

Références

Nat Neurosci. 2018 Dec;21(12):1656-1669
pubmed: 30482948
Neuroimage. 2018 Sep;178:540-551
pubmed: 29860082
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Neurobiol Dis. 2015 Jan;73:213-9
pubmed: 25315685
JAMA Psychiatry. 2015 Mar;72(3):268-75
pubmed: 25629589
Netw Neurosci. 2018 Oct 01;3(1):107-123
pubmed: 30793076
Mol Psychiatry. 2019 Jul;24(7):952-964
pubmed: 30315224
Nat Biotechnol. 2019 Jul;37(7):773-782
pubmed: 31061481
Sci Data. 2015 Jul 07;2:150031
pubmed: 26175908
Curr Drug Targets. 2013 Oct;14(11):1225-36
pubmed: 23469922
Nat Neurosci. 2018 Sep;21(9):1251-1259
pubmed: 30082915
Cereb Cortex. 2001 Oct;11(10):975-88
pubmed: 11549620
Cell. 2017 Oct 5;171(2):456-469.e22
pubmed: 28985566
Nature. 1987 Jul 9-15;328(6126):175-8
pubmed: 2885756
Science. 2015 Jun 12;348(6240):1241-4
pubmed: 26068849
J Neurosci. 2012 Dec 12;32(50):18087-100
pubmed: 23238724
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9050-9059
pubmed: 30988201
J Affect Disord. 2010 Dec;127(1-3):230-40
pubmed: 20580095
Nature. 2019 Sep;573(7772):61-68
pubmed: 31435019
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Mol Psychiatry. 2017 Jun;22(6):920-930
pubmed: 27821870
Nat Neurosci. 2019 Feb;22(2):154-166
pubmed: 30664773
Cell. 2018 Jun 14;173(7):1573-1580
pubmed: 29906445
Nat Commun. 2018 Jan 8;9(1):82
pubmed: 29311610
Biol Psychiatry. 2017 Oct 15;82(8):549-559
pubmed: 28697889
Biol Psychiatry. 2020 Aug 1;88(3):248-259
pubmed: 32029217
Nat Commun. 2018 Apr 12;9(1):1428
pubmed: 29651138
Arch Gen Psychiatry. 1987 Jun;44(6):573-88
pubmed: 3579504
J Neuropsychiatry Clin Neurosci. 1997 Summer;9(3):471-81
pubmed: 9276848
Hum Brain Mapp. 2020 Mar 21;:
pubmed: 32198905
Arch Gen Psychiatry. 2001 Jun;58(6):545-53
pubmed: 11386983
Nat Commun. 2020 Jul 3;11(1):3358
pubmed: 32620757
Am J Psychiatry. 2000 Oct;157(10):1552-62
pubmed: 11007705
PLoS One. 2013 Nov 25;8(11):e75362
pubmed: 24282498
Hum Brain Mapp. 2016 Sep;37(9):3214-23
pubmed: 27144347
Biol Psychiatry. 2017 May 15;81(10):886-897
pubmed: 27449797
Neuropsychopharmacology. 2018 Apr;43(5):1119-1127
pubmed: 28944772
Neuron. 2005 Oct 20;48(2):175-87
pubmed: 16242399
Nat Commun. 2018 Oct 12;9(1):4254
pubmed: 30315174
Nat Neurosci. 2016 Nov;19(11):1523-1536
pubmed: 27643430
Biol Psychiatry. 2020 Apr 15;87(8):717-726
pubmed: 31858985
Nat Genet. 2018 Jun;50(6):825-833
pubmed: 29785013
Nat Commun. 2019 Jul 19;10(1):3222
pubmed: 31324783
Brain. 2018 Sep 1;141(9):2755-2771
pubmed: 30016411
Mol Psychiatry. 2017 Jun;22(6):900-909
pubmed: 27137745
Mol Psychiatry. 2019 Jul;24(7):1053-1064
pubmed: 29483624
Nat Neurosci. 2020 Jan;23(1):47-60
pubmed: 31844317
Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E469-78
pubmed: 26739559
Int J Neuropsychopharmacol. 2011 Jul;14(6):721-34
pubmed: 21226980
Nat Genet. 2018 May;50(5):668-681
pubmed: 29700475
Neuropsychopharmacology. 2010 Jan;35(1):192-216
pubmed: 19693001
Nat Med. 2017 Sep;23(9):1102-1111
pubmed: 28825715
Brain Struct Funct. 2008 Sep;213(1-2):93-118
pubmed: 18704495
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13290-5
pubmed: 9789081
Neuron. 2012 Oct 4;76(1):98-115
pubmed: 23040809
Nat Genet. 2020 Apr;52(4):437-447
pubmed: 32231276
JAMA Psychiatry. 2015 Jun;72(6):603-11
pubmed: 25785575
Nat Commun. 2020 Jun 8;11(1):2889
pubmed: 32514083
Science. 2018 Feb 9;359(6376):693-697
pubmed: 29439242
Cereb Cortex. 2002 Apr;12(4):386-94
pubmed: 11884354
Cereb Cortex. 2018 Sep 1;28(9):3095-3114
pubmed: 28981612
Am J Psychiatry. 2009 Jun;166(6):702-10
pubmed: 19411368
Curr Opin Neurobiol. 2001 Apr;11(2):231-9
pubmed: 11301245
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Trends Immunol. 2006 Jan;27(1):24-31
pubmed: 16316783
Mol Psychiatry. 2011 Jun;16(6):604-19
pubmed: 21602829
Cereb Cortex. 2016 Jan;26(1):288-303
pubmed: 25316338
Nat Genet. 2015 Nov;47(11):1228-35
pubmed: 26414678
Neuron. 2018 Jan 17;97(2):263-268
pubmed: 29346749
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Biotechnol. 2018 Jan;36(1):70-80
pubmed: 29227469
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4689-4695
pubmed: 30782826
Mol Psychiatry. 2016 Jun;21(6):806-12
pubmed: 26122586
Sci Rep. 2017 Aug 31;7(1):10149
pubmed: 28860455
Nat Rev Genet. 2019 May;20(5):257-272
pubmed: 30696980
Neuroimage. 2016 Sep;138:147-163
pubmed: 27177763
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Biol Psychiatry. 2017 Mar 15;81(6):495-502
pubmed: 27720199
Nat Commun. 2020 Feb 19;11(1):960
pubmed: 32075960
Invest Radiol. 2005 Dec;40(12):754-60
pubmed: 16304477
Cold Spring Harb Perspect Biol. 2015 Feb 06;7(9):a020370
pubmed: 25663667
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9604-9609
pubmed: 31004051
Depress Anxiety. 2017 Jan;34(1):68-78
pubmed: 27557481
Biol Psychiatry. 2019 Mar 15;85(6):517-526
pubmed: 30449530
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Nat Med. 2001 May;7(5):541-7
pubmed: 11329053
Neuroimage. 2018 May 1;171:256-267
pubmed: 29274746
Neurobiol Dis. 2011 Apr;42(1):116-24
pubmed: 21232602
Biol Psychiatry. 1999 May 1;45(9):1085-98
pubmed: 10331101
Mol Psychiatry. 2011 Jul;16(7):751-62
pubmed: 20479761
Biol Psychiatry. 2015 Feb 1;77(3):285-294
pubmed: 25109665
Neuron. 2019 Apr 3;102(1):75-90
pubmed: 30946828
Neuroscientist. 2014 Dec;20(6):652-64
pubmed: 24622818
Nat Genet. 2018 Apr;50(4):621-629
pubmed: 29632380
Trends Cogn Sci. 2018 Mar;22(3):241-257
pubmed: 29475637
Front Neuroinform. 2011 Jun 27;5:4
pubmed: 21743807
Neuroimage. 2017 Oct 1;159:57-69
pubmed: 28712995
Nat Commun. 2018 Aug 1;9(1):3003
pubmed: 30068943
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11
pubmed: 19465376
Nat Rev Drug Discov. 2017 Jul;16(7):472-486
pubmed: 28303025

Auteurs

Kevin M Anderson (KM)

Department of Psychology, Yale University, New Haven, CT 06520; kevin.anderson@yale.edu.
ORCID: 0000-0002-9446-7386

Meghan A Collins (MA)

Department of Psychology, Yale University, New Haven, CT 06520.
ORCID: 0000-0002-2534-1798

Ru Kong (R)

Department of Electrical and Computer Engineering, National University of Singapore, Singapore.
Centre for Sleep and Cognition, National University of Singapore, Singapore.
Clinical Imaging Research Centre, National University of Singapore, Singapore.
N.1 Institute for Health, National University of Singapore, Singapore.
Institute for Digital Medicine, National University of Singapore, Singapore.
ORCID: 0000-0001-7842-0329

Kacey Fang (K)

Department of Psychology, Yale University, New Haven, CT 06520.

Jingwei Li (J)

Department of Electrical and Computer Engineering, National University of Singapore, Singapore.
Centre for Sleep and Cognition, National University of Singapore, Singapore.
Clinical Imaging Research Centre, National University of Singapore, Singapore.
N.1 Institute for Health, National University of Singapore, Singapore.
Institute for Digital Medicine, National University of Singapore, Singapore.

Tong He (T)

Department of Electrical and Computer Engineering, National University of Singapore, Singapore.
Centre for Sleep and Cognition, National University of Singapore, Singapore.
Clinical Imaging Research Centre, National University of Singapore, Singapore.
N.1 Institute for Health, National University of Singapore, Singapore.
Institute for Digital Medicine, National University of Singapore, Singapore.

Adam M Chekroud (AM)

Department of Psychiatry, Yale University, New Haven, CT 06520.
Spring Health, New York, NY 10001.
ORCID: 0000-0002-0497-596X

B T Thomas Yeo (BTT)

Department of Electrical and Computer Engineering, National University of Singapore, Singapore.
Centre for Sleep and Cognition, National University of Singapore, Singapore.
Clinical Imaging Research Centre, National University of Singapore, Singapore.
N.1 Institute for Health, National University of Singapore, Singapore.
Institute for Digital Medicine, National University of Singapore, Singapore.
Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
ORCID: 0000-0002-0119-3276

Avram J Holmes (AJ)

Department of Psychology, Yale University, New Haven, CT 06520.
Department of Psychiatry, Yale University, New Haven, CT 06520.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0001-6583-803X

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