Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.
Journal
Human genetics
ISSN: 1432-1203
Titre abrégé: Hum Genet
Pays: Germany
ID NLM: 7613873
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
21
05
2020
accepted:
02
09
2020
pubmed:
23
9
2020
medline:
9
3
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (P
Identifiants
pubmed: 32959083
doi: 10.1007/s00439-020-02223-6
pii: 10.1007/s00439-020-02223-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-552Subventions
Organisme : National Health and Medical Research Council (AU)
ID : 1,050,208
Organisme : National Health and Medical Research Council (AU)
ID : 241,944, 339,462, 389,927, 389,875, 389,891, 389,892, 389,938, 443,036, 442,915, 442,981, 496,610, 496,739, 552,485, 552,498, 1,026,033
Organisme : Wellcome Trust
ID : 085475
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 076113
Pays : United Kingdom
Organisme : The Lundbeck Foundation, Denmark
ID : R155-2014-1724
Organisme : The Lundbeck Foundation, Denmark
ID : R102-A9118
Investigateurs
Yadav Sapkota
(Y)
Kosuke Yoshihara
(K)
Mette Nyegaard
(M)
Valgerdur Steinthorsdottir
(V)
Andrew P Morris
(AP)
Amelie Fassbender
(A)
Nilufer Rahmioglu
(N)
Immaculata De Vivo
(I)
Julie E Buring
(JE)
Futao Zhang
(F)
Todd L Edwards
(TL)
Sarah Jones
(S)
None Dorien
Daniëlle Peterse
(D)
Kathryn M Rexrode
(KM)
Paul M Ridker
(PM)
Andrew J Schork
(AJ)
Stuart MacGregor
(S)
Nicholas G Martin
(NG)
Christian M Becker
(CM)
Sosuke Adachi
(S)
Takayuki Enomoto
(T)
Atsushi Takahashi
(A)
Yoichiro Kamatani
(Y)
Koichi Matsuda
(K)
Michiaki Kubo
(M)
Gudmar Thorleifsson
(G)
Reynir T Geirsson
(RT)
Unnur Thorsteinsdottir
(U)
Leanne M Wallace
(LM)
Jian Yang
(J)
Digna R Velez Edwards
(DR)
Mette Nyegaard
(M)
Siew-Kee Low
(SK)
Krina T Zondervan
(KT)
Stacey A Missmer
(SA)
Thomas D'Hooghe
(T)
Kari Stefansson
(K)
Joyce Y Tung
(JY)
Grant W Montgomery
(GW)
Daniel I Chasman
(DI)
Dale R Nyholt
(DR)
Michelle Agee
(M)
Babak Alipanahi
(B)
Adam Auton
(A)
Robert K Bell
(RK)
Katarzyna Bryc
(K)
Sarah L Elson
(SL)
Pierre Fontanillas
(P)
Nicholas A Furlotte
(NA)
Karen E Huber
(KE)
Aaron Kleinman
(A)
Nadia K Litterman
(NK)
Matthew H McIntyre
(MH)
Joanna L Mountain
(JL)
Elizabeth S Noblin
(ES)
Carrie A M Northover
(CAM)
Steven J Pitts
(SJ)
J Fah Sathirapongsasuti
(J)
Olga V Sazonova
(OV)
Janie F Shelton
(JF)
Suyash Shringarpure
(S)
Chao Tian
(C)
Vladimir Vacic
(V)
Catherine H Wilson
(CH)
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