Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.
Bile
/ chemistry
Bile Acids and Salts
/ metabolism
Biological Availability
Caprylates
/ administration & dosage
Cell Membrane
/ metabolism
Cell Membrane Permeability
/ drug effects
Decanoates
/ administration & dosage
Drug Delivery Systems
/ methods
Healthy Volunteers
Humans
Intestinal Absorption
/ drug effects
Intestinal Mucosa
/ drug effects
Macromolecular Substances
/ administration & dosage
Molecular Dynamics Simulation
Phospholipids
/ metabolism
SNAC
coarse-grained molecular dynamics
medium-chain fatty acids
membrane incorporation
molecular simulation
transient permeability enhancers
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
02 11 2020
02 11 2020
Historique:
pubmed:
23
9
2020
medline:
15
9
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
Transient permeability enhancers (PEs), such as caprylate, caprate, and salcaprozate sodium (SNAC), improve the bioavailability of poorly permeable macromolecular drugs. However, the effects are variable across individuals and classes of macromolecular drugs and biologics. Here, we examined the influence of bile compositions on the ability of membrane incorporation of three transient PEs-caprylate, caprate, and SNAC-using coarse-grained molecular dynamics (CG-MD). The availability of free PE monomers, which are important near the absorption site, to become incorporated into the membrane was higher in fasted-state fluids than that in fed-state fluids. The simulations also showed that transmembrane perturbation,
Identifiants
pubmed: 32960068
doi: 10.1021/acs.molpharmaceut.0c00668
pmc: PMC7610231
doi:
Substances chimiques
Bile Acids and Salts
0
Caprylates
0
Decanoates
0
Macromolecular Substances
0
N-(8-(2-hydroxybenzoyl)amino)caprylate
0
Phospholipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4226-4240Références
Biochim Biophys Acta. 2011 Nov;1808(11):2761-71
pubmed: 21819968
Langmuir. 2014 Sep 9;30(35):10661-7
pubmed: 25133680
Soft Matter. 2016 Jun 21;12(23):5172-9
pubmed: 27199094
J Comput Chem. 2009 Oct;30(13):2157-64
pubmed: 19229944
Scand J Clin Lab Invest. 1988 Sep;48(5):381-8
pubmed: 3060983
Cancer Res. 1979 May;39(5):1726-32
pubmed: 218733
J Colloid Interface Sci. 2002 Jan 1;245(1):1-15
pubmed: 16290329
J Chem Phys. 2010 Mar 21;132(11):114902
pubmed: 20331315
J Pharmacol Exp Ther. 1995 Nov;275(2):958-64
pubmed: 7473188
Diabetes Care. 2019 Sep;42(9):1724-1732
pubmed: 31186300
Lancet Diabetes Endocrinol. 2019 Jul;7(7):528-539
pubmed: 31189520
Langmuir. 2015 Feb 3;31(4):1336-43
pubmed: 25560633
Nanoscale. 2017 Mar 23;9(12):4114-4127
pubmed: 28280822
J Phys Chem B. 2009 Aug 6;113(31):10715-20
pubmed: 19591445
Pharmaceutics. 2019 Feb 13;11(2):
pubmed: 30781867
Int J Mol Sci. 2016 Aug 18;17(8):
pubmed: 27548141
Mol Pharm. 2016 Oct 3;13(10):3484-3493
pubmed: 27576295
J Comput Chem. 2013 Dec 15;34(32):2757-70
pubmed: 24000174
Lancet Diabetes Endocrinol. 2019 Jul;7(7):515-527
pubmed: 31189517
Gan. 1953 Dec;44(4):421-7
pubmed: 13151348
Ther Deliv. 2011 Dec;2(12):1595-610
pubmed: 22833984
Biochem J. 1994 Jun 1;300 ( Pt 2):509-18
pubmed: 8002957
Nano Lett. 2012 Nov 14;12(11):5719-25
pubmed: 23092308
Nat Protoc. 2010 Jun;5(6):1096-106
pubmed: 20539285
AAPS PharmSciTech. 2019 Jan 9;20(2):61
pubmed: 30627943
J Phys Chem B. 2017 Dec 7;121(48):10869-10881
pubmed: 29090933
N Engl J Med. 2019 Aug 29;381(9):841-851
pubmed: 31185157
Clin Chim Acta. 1987 May 29;165(1):27-37
pubmed: 3111757
Diabetes Care. 2019 Dec;42(12):2272-2281
pubmed: 31530666
Ther Deliv. 2010 Jul;1(1):75-82
pubmed: 22816121
Adv Drug Deliv Rev. 2009 Dec 17;61(15):1427-49
pubmed: 19800376
Eur J Pharm Biopharm. 2019 Sep;142:387-395
pubmed: 31306752
Lancet Diabetes Endocrinol. 2020 May;8(5):392-406
pubmed: 32333876
J Chem Inf Model. 2012 Dec 21;52(12):3144-54
pubmed: 23146088
Curr Drug Deliv. 2005 Apr;2(2):191-7
pubmed: 16305420
Langmuir. 2010 Jun 15;26(12):9378-85
pubmed: 20462279
Biomaterials. 2013 Jan;34(1):275-82
pubmed: 23069717
J Pharm Sci. 2016 Feb;105(2):673-681
pubmed: 26228456
Sci Rep. 2019 Feb 6;9(1):1456
pubmed: 30728438
Expert Opin Drug Deliv. 2006 Sep;3(5):685-92
pubmed: 16948563
Lancet Diabetes Endocrinol. 2020 May;8(5):377-391
pubmed: 32333875
JAMA. 2019 Apr 16;321(15):1466-1480
pubmed: 30903796
AAPS J. 2012 Mar;14(1):10-8
pubmed: 22105442
J Chem Theory Comput. 2015 May 12;11(5):2144-55
pubmed: 26574417
Sci Transl Med. 2018 Nov 14;10(467):
pubmed: 30429357
Biophys J. 2008 Dec;95(11):5334-48
pubmed: 18567628
Lancet. 2019 Jul 6;394(10192):39-50
pubmed: 31186120
Pharm Res. 2014 Aug;31(8):2010-21
pubmed: 24558008
Mol Pharm. 2020 Oct 5;17(10):3837-3844
pubmed: 32787279
Eur J Pharm Biopharm. 2020 Jul;152:95-107
pubmed: 32387703
Phys Rev E. 2019 Jul;100(1-1):012603
pubmed: 31499829
J Pharm Sci. 2019 Jan;108(1):205-213
pubmed: 30395831
Eur J Pharm Biopharm. 2014 Nov;88(3):830-39
pubmed: 25460147
Biochim Biophys Acta. 1974 Nov 18;369(2):222-33
pubmed: 4371841
J Comput Chem. 2013 Sep 30;34(25):2135-45
pubmed: 23832629
J Comput Chem. 2014 Oct 15;35(27):1997-2004
pubmed: 25130509
J Chem Inf Model. 2012 Dec 21;52(12):3155-68
pubmed: 23145473
Q Rev Biophys. 2008 Aug-Nov;41(3-4):205-64
pubmed: 19079805
J Pharm Sci. 2008 Jan;97(1):225-36
pubmed: 17721945
Mol Pharm. 2015 Jul 6;12(7):2245-53
pubmed: 25874852
Lancet Diabetes Endocrinol. 2019 Mar;7(3):179-188
pubmed: 30679095
J Phys Chem B. 2007 Jul 12;111(27):7812-24
pubmed: 17569554
Pharm Res. 1993 Jun;10(6):857-64
pubmed: 8321854
Pharmaceutics. 2019 Jan 19;11(1):
pubmed: 30669434
Diabetes Care. 2019 Dec;42(12):2262-2271
pubmed: 31530667