Recalibrating Health Technology Assessment Methods for Cell and Gene Therapies.
Journal
PharmacoEconomics
ISSN: 1179-2027
Titre abrégé: Pharmacoeconomics
Pays: New Zealand
ID NLM: 9212404
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
23
9
2020
medline:
18
9
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
Recently licensed cell and gene therapies have promising but highly uncertain clinical benefits. They are entering the market at very high prices, with the latest entrants costing hundreds of thousands of dollars. The significant long-term uncertainty posed by these therapies has already complicated the use of conventional economic evaluation approaches such as cost-effectiveness and cost-utility analyses, which are widely used for assessing the value of new health interventions. Cell and gene therapies also risk jeopardising healthcare systems' financial sustainability. As a result, there is a need to recalibrate the current health technology assessment methods used to measure and compensate their value. In this paper, we outline a set of technical adaptations and methodological refinements to address key challenges in the appraisal of cell and gene therapies' value, including the assessment of efficiency and affordability. We also discuss the potential role of alternative financing mechanisms. Ultimately, uncertainties associated with cell and gene therapies can only be meaningfully addressed by improving the evidence base supporting their approval and adoption in healthcare systems.
Identifiants
pubmed: 32960434
doi: 10.1007/s40273-020-00956-w
pii: 10.1007/s40273-020-00956-w
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1297-1308Références
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