Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
ATPases Associated with Diverse Cellular Activities
/ genetics
Animals
Cell Proliferation
Chromatin
DNA Glycosylases
/ genetics
DNA-Binding Proteins
/ genetics
Epigenomics
Gene Expression Regulation, Enzymologic
Humans
Hypertrophy
/ metabolism
Male
Mice
Mice, Knockout
Muscle, Skeletal
/ cytology
Myoblasts
/ cytology
RNA, Long Noncoding
/ genetics
RNA, Untranslated
Regeneration
/ physiology
Transcriptome
YY1 Transcription Factor
/ genetics
Chromatin remodeler
lincRNA
muscle stem cell proliferation
non-coding RNA function
satellite cell
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
16 11 2020
16 11 2020
Historique:
received:
25
03
2020
revised:
20
08
2020
accepted:
24
08
2020
pubmed:
23
9
2020
medline:
15
4
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
Chromatin remodeling complexes have functions in transcriptional regulation and chromosome maintenance, but it is mostly unknown how the function of these normally ubiquitous complexes is specified in the cellular context. Here, we describe that the evolutionary conserved long non-coding RNA linc-MYH regulates the composition of the INO80 chromatin remodeler complex in muscle stem cells and prevents interaction with WDR5 and the transcription factor YY1. Linc-MYH acts as a selective molecular switch in trans that governs the pro-proliferative function of the ubiquitous INO80 complex but does not affect its role in maintaining genomic stability. The molecular switch is essential for restricting generation of quiescent MuSCs and proliferation of myoblasts in homeostasis and regeneration. Since linc-MYH is expressed in proliferating myoblasts but not in quiescent MuSCs, we reason that the extent of myoblast proliferation has decisive effects on the size of the quiescent MuSC pool.
Identifiants
pubmed: 32960481
doi: 10.15252/embj.2020105098
pmc: PMC7667881
doi:
Substances chimiques
Chromatin
0
DNA-Binding Proteins
0
RNA, Long Noncoding
0
RNA, Untranslated
0
YY1 Transcription Factor
0
Yy1 protein, mouse
0
DNA Glycosylases
EC 3.2.2.-
mutY adenine glycosylase
EC 3.2.2.-
ATPases Associated with Diverse Cellular Activities
EC 3.6.4.-
INO80 protein, human
EC 3.6.4.-
INO80 protein, mouse
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e105098Subventions
Organisme : Max-Planck-Gesellschaft (MPG)
Organisme : Loewe Network Medical RNomics
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : RTG2355
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : TRR267
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : TRR81
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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