Changes in conjugated urinary bile acids across age groups.
Adolescent
Adult
Bile Acids and Salts
/ standards
Child
Child, Preschool
Chromatography, Liquid
/ methods
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Reference Standards
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization
/ methods
Tandem Mass Spectrometry
/ methods
Young Adult
Conjugation
Hydrophobicity
LC-MS/MS
Physiologic cholestasis
Urinary bile acids
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
04
2020
revised:
07
08
2020
accepted:
06
09
2020
pubmed:
23
9
2020
medline:
15
10
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
Bile acid compositions are known to change dramatically after birth with aging. However, no reports have described the transition of conjugated urinary bile acids from the neonatal period to adulthood, and such findings would noninvasively offer insights into hepatic function. The aim of this study was to investigate differences in bile acid species, conjugation rates, and patterns, and to pool characteristics for age groups. We measured urinary bile acids in spot urine samples from 92 healthy individuals ranging from birth to 58 years old using liquid chromatography tandem mass spectrometry (LC/ESI-MS/MS). Sixty-six unconjugated and conjugated bile acids were systematically determined. After birth, urinary bile acids dramatically changed from fetal (i.e., Δ
Identifiants
pubmed: 32961239
pii: S0039-128X(20)30156-2
doi: 10.1016/j.steroids.2020.108730
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108730Subventions
Organisme : BLRD VA
ID : I01 BX000197
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.