Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities.
Diagnostics
EVs
Exosomes
Liver disease
Microvesicles
Therapeutics
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
27
07
2020
accepted:
09
09
2020
pubmed:
23
9
2020
medline:
14
1
2022
entrez:
22
9
2020
Statut:
ppublish
Résumé
Since the first descriptions of hepatocyte-released exosome-like vesicles in 2008, the number of publications describing Extracellular Vesicles (EVs) released by liver cells in the context of hepatic physiology and pathology has grown exponentially. This growing interest highlights both the importance that cell-to-cell communication has in the organization of multicellular organisms from a physiological point of view, as well as the opportunity that these circulating organelles offer in diagnostics and therapeutics. In the present review, we summarize systematically and comprehensively the myriad of works that appeared in the last decade and lighted the discussion about the best opportunities for using EVs in liver disease therapeutics.
Identifiants
pubmed: 32961265
pii: S0163-7258(20)30213-8
doi: 10.1016/j.pharmthera.2020.107683
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107683Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest.