Vitamin A regulates fibroblast growth factor 23 (FGF23).

Calcitriol Fibroblast Growth Factor-23 Fibroblast Growth Factors / genetics Receptors, Calcitriol Vitamin A
Klotho Micronutrients Phosphate Retinoic acid receptor Retinoids Vitamin D

Journal

Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712

Informations de publication

Date de publication:
Historique:
received: 21 04 2020
revised: 02 07 2020
accepted: 28 07 2020
pubmed: 23 9 2020
medline: 24 6 2021
entrez: 22 9 2020
Statut: ppublish

Résumé

Renal phosphate and vitamin D metabolism are regulated by proteohormone fibroblast growth factor 23 (FGF23), which is secreted by bone cells. FGF23 inhibits phosphate reabsorption and the production of calcitriol, active vitamin D (1,25(OH) We studied the relevance of vitamin A for FGF23 production. Fgf23 transcripts were determined by real-time quantitative polymerase chain reaction in UMR106 osteoblast-like cells and IDG-SW3 osteocytes. FGF23 protein in the cell culture supernatant was measured by enzyme-linked immunosorbent assay. All-trans-retinoic acid, retinyl acetate, RAR agonist TTNPB (4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid), and 13-cis-retinoic acid downregulated the expression of the Fgf23 gene in a dose-dependent manner. This effect was significantly attenuated by RAR antagonist AGN193109 (4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid). The present study demonstrated that vitamin A is a potent suppressor of FGF23 production through RAR.

Identifiants

DOI: 10.1016/j.nut.2020.110988 PMID: 32961447
pubmed: 32961447
pii: S0899-9007(20)30271-9
doi: 10.1016/j.nut.2020.110988
pii:
doi:

Substances chimiques

Receptors, Calcitriol 0
Vitamin A 11103-57-4
Fibroblast Growth Factors 62031-54-3
Fibroblast Growth Factor-23 7Q7P4S7RRE
Calcitriol FXC9231JVH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110988

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Steffen Rausch (S)

Department of Physiology, University of Hohenheim, Stuttgart, Germany.

Michelle Barholz (M)

Department of Physiology, University of Hohenheim, Stuttgart, Germany.

Michael Föller (M)

Department of Physiology, University of Hohenheim, Stuttgart, Germany.

Martina Feger (M)

Department of Physiology, University of Hohenheim, Stuttgart, Germany. Electronic address: martina.feger@uni-hohenheim.de.

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Classifications MeSH

questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Hydroxycholécalciférols › Dihydroxycholécalciférols › Calcitriol › Vitamin A regulates fibroblast growth factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Facteur-23 de croissance des fibroblastes › Vitamin A regulates fibroblast growth factor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Vitamin A regulates fibroblast growth factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur calcitriol › Vitamin A regulates fibroblast growth factor...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Rétinoïdes › Rétinol › Vitamin A regulates fibroblast growth factor...