Neurocognitive vulnerability to youth suicidal behavior.

Adolescent Adult Child Depressive Disorder, Major Female Humans Male Neuropsychological Tests Prospective Studies Suicidal Ideation Suicide, Attempted
Adolescent mental health Neurocognitive functioning Prevention/early detection Suicidal behavior Suicide risks

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
12 2020
Historique:
received: 09 04 2020
revised: 09 06 2020
accepted: 25 08 2020
pubmed: 23 9 2020
medline: 15 5 2021
entrez: 22 9 2020
Statut: ppublish

Résumé

Neurocognitive deficits have been associated with suicidal behavior in adults with major depressive disorder (MDD), but it is unclear if similar impairments are linked to youth suicidal behavior. This study compared neurocognitive functioning in suicidal and non-suicidal youth with a lifetime history of MDD and explored whether neurocognitive functioning predicted future suicide attempts. Neurocognition was examined using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and Iowa Gambling Task (IGT) in 309 youths ages 12-15 (117 suicide attempters; 132 suicidal ideators; 60 never-suicidal). Prospective analyses included 284 youths (41 youth with a future attempt; 243 without a future attempt). Multivariate analysis of variance (MANOVA) yielded a significant group-by-sex interaction effect [Wilks' Λ = 0.901, F (16, 560) = 1.87, p = .021] for the primary neurocognitive outcomes, guiding the decision to stratify the sample by sex. Female suicide attempters and ideators were slower to respond correctly to both positive and negative emotion words than never-suicidal controls on tests of affective bias. Male suicide attempters and ideators made significantly more total and between errors than never-suicidal subjects. Exploratory analyses found that total commission errors on the Affective Go/No-Go (AGN) test significantly predicted future suicide attempts in females, and that higher strategy scores on Spatial Working Memory (SWM) tests predicted future male attempts. Study findings identified sex-specific neurocognitive deficits that differentiate suicidal and non-suicidal youth with histories of MDD. Extended longitudinal studies are needed to elucidate the temporal association between neurocognitive impairments and suicidal behavior and frame targets for early preventive interventions.

Identifiants

DOI: 10.1016/j.jpsychires.2020.08.032 PMID: 32961501 PMC: PMC7669668
pubmed: 32961501
pii: S0022-3956(20)30944-4
doi: 10.1016/j.jpsychires.2020.08.032
pmc: PMC7669668
mid: NIHMS1630867
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

119-126

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH093552
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Donna Ruch (D)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA. Electronic address: Donna.Ruch@nationwidechildrens.org.

Arielle H Sheftall (AH)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA; The Ohio State University Wexner Medical Center, College of Medicine - Department of Psychiatry and Behavioral Health 370 W. 9th Avenue, Columbus, OH, 43210, USA.

Kendra Heck (K)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA.

Sandra M McBee-Strayer (SM)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA.

Jaclyn Tissue (J)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA.

Brady Reynolds (B)

University of Kentucky, College of Medicine - Medical Behavioral Science Building, 800 Rose Street MN 150, Lexington, KY, 40506, USA.

John Ackerman (J)

The Ohio State University Wexner Medical Center, College of Medicine - Department of Psychiatry and Behavioral Health 370 W. 9th Avenue, Columbus, OH, 43210, USA; Big Lots Behavioral Health Pavilion Nationwide Children's Hospital, 444 Butterfly Gardens Dr., Columbus, OH, 43215, USA.

David A Brent (DA)

University of Pittsburgh, Department of Psychiatry Thomas Detre Hall, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.

John V Campo (JV)

West Virginia University, Department of Behavioral Medicine and Psychiatry, 930 Chestnut Ridge Rd, Morgantown, WV, 26505, USA.

Jeffrey A Bridge (JA)

The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Suicide Prevention and Research, 700 Children's Drive, 3rd Floor FOB, Columbus, OH, 43205, USA; The Ohio State University Wexner Medical Center, College of Medicine - Department of Psychiatry and Behavioral Health 370 W. 9th Avenue, Columbus, OH, 43210, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Neurocognitive vulnerability to youth suicidal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Neurocognitive vulnerability to youth suicidal...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Neurocognitive vulnerability to youth suicidal...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Neurocognitive vulnerability to youth suicidal...
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questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Suicide › Idéation suicidaire › Neurocognitive vulnerability to youth suicidal...
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