Signal Transduction Pathway Activity in High-Grade, Serous Ovarian Carcinoma Reveals a More Favorable Prognosis in Tumors with Low PI3K and High NF-κB Pathway Activity: A Novel Approach to a Long-Standing Enigma.
cluster analysis
epithelial ovarian cancer
high-grade serous ovarian cancer
progression-free survival
signal transduction pathways
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Sep 2020
18 Sep 2020
Historique:
received:
04
08
2020
revised:
09
09
2020
accepted:
11
09
2020
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
24
9
2020
Statut:
epublish
Résumé
We investigated signal transduction pathway (STP) activity in high-grade serous ovarian carcinoma (HGSC) in relation to progression-free survival (PFS) and overall survival (OS). We made use of signal transduction pathway activity analysis (STA analysis), a novel method to quantify functional STP activity. Activity of the following pathways was measured: androgen receptor (AR), estrogen receptor (ER), phosphoinositide 3-kinase (PI3K), Hedgehog (Hh), Notch, nuclear factor-kappa B (NF-κB), transforming growth factor beta (TGF-β), and Wnt. We selected HGSC samples from publicly available datasets of ovarian cancer tissue, and used repeated
Identifiants
pubmed: 32961868
pii: cancers12092660
doi: 10.3390/cancers12092660
pmc: PMC7564278
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Research and Materiel Command
ID : DAMD17-01-1-0729
Organisme : National Health and Medical Research Council
ID : ID199600
Organisme : National Health and Medical Research Council
ID : ID400413
Organisme : National Health and Medical Research Council
ID : ID400281
Organisme : National Health and Medical Research Council
ID : ID 310670
Organisme : National Health and Medical Research Council
ID : ID 628903
Organisme : Cancer Institute NSW
ID : ID 12/RIG/1-17
Organisme : Cancer Institute NSW
ID : 15/RIG/1-16
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