Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.
AcrAB-TolC efflux pump
atypical tetracyclines
broad-spectrum antibiotics
chelocardins
clinical isolates
mechanism of resistance
resistance-breaking properties
urinary tract infection (UTI)
uropathogens
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
18 Sep 2020
18 Sep 2020
Historique:
received:
23
08
2020
revised:
16
09
2020
accepted:
17
09
2020
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
24
9
2020
Statut:
epublish
Résumé
The reassessment of known but neglected natural compounds is a vital strategy for providing novel lead structures urgently needed to overcome antimicrobial resistance. Scaffolds with resistance-breaking properties represent the most promising candidates for a successful translation into future therapeutics. Our study focuses on chelocardin, a member of the atypical tetracyclines, and its bioengineered derivative amidochelocardin, both showing broad-spectrum antibacterial activity within the ESKAPE (
Identifiants
pubmed: 32962088
pii: antibiotics9090619
doi: 10.3390/antibiotics9090619
pmc: PMC7559539
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsches Zentrum für Infektionsforschung
ID : TTU09.814, TTU09.821, 80325CLMOF, 8032808818, 8032808819, 8032808820
Organisme : Ministry of Higher Education, Science and Technology, Slovenian Research Agency
ID : J4-8226, P4-0116
Organisme : SPIRIT Slovenija
ID : P-MR-09/104
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