Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 09 2020
22 09 2020
Historique:
received:
04
03
2020
accepted:
20
08
2020
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Identifiants
pubmed: 32963231
doi: 10.1038/s41467-020-18367-y
pii: 10.1038/s41467-020-18367-y
pmc: PMC7508833
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, American Recovery and Reinvestment Act
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4796Subventions
Organisme : NHLBI NIH HHS
ID : HHSN268201100008C
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
Organisme : Medical Research Council
ID : G0700704
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100009C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087652
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M01311/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001401
Pays : United Kingdom
Organisme : CIHR
ID : TMH109788
Pays : Canada
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F019394/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100007C
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ID : R01 HL120393
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Organisme : NIBIB NIH HHS
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ID : HHSN268201200036C
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Organisme : NHLBI NIH HHS
ID : RC2 HL102419
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS087541
Pays : United States
Organisme : Medical Research Council
ID : MR/R024065/1
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Organisme : NHLBI NIH HHS
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Pays : United States
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Organisme : NIA NIH HHS
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Pays : United States
Organisme : Medical Research Council
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Pays : United Kingdom
Organisme : NIA NIH HHS
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Pays : United States
Investigateurs
Katrina L Grasby
(KL)
Neda Jahanshad
(N)
Jodie N Painter
(JN)
Lucía Colodro-Conde
(L)
Janita Bralten
(J)
Derrek P Hibar
(DP)
Penelope A Lind
(PA)
Fabrizio Pizzagalli
(F)
Christopher R K Ching
(CRK)
Mary Agnes B McMahon
(MAB)
Natalia Shatokhina
(N)
Leo C P Zsembik
(LCP)
Ingrid Agartz
(I)
Saud Alhusaini
(S)
Marcio A A Almeida
(MAA)
Dag Alnæs
(D)
Inge K Amlien
(IK)
Micael Andersson
(M)
Tyler Ard
(T)
Nicola J Armstrong
(NJ)
Allison Ashley-Koch
(A)
Manon Bernard
(M)
Rachel M Brouwer
(RM)
Elizabeth E L Buimer
(EEL)
Robin Bülow
(R)
Christian Bürger
(C)
Dara M Cannon
(DM)
Mallar Chakravarty
(M)
Qiang Chen
(Q)
Joshua W Cheung
(JW)
Baptiste Couvy-Duchesne
(B)
Anders M Dale
(AM)
Shareefa Dalvie
(S)
Tânia K de Araujo
(TK)
Greig I de Zubicaray
(GI)
Sonja M C de Zwarte
(SMC)
Anouk den Braber
(A)
Nhat Trung Doan
(NT)
Katharina Dohm
(K)
Stefan Ehrlich
(S)
Hannah-Ruth Engelbrecht
(HR)
Susanne Erk
(S)
Chun Chieh Fan
(CC)
Iryna O Fedko
(IO)
Sonya F Foley
(SF)
Judith M Ford
(JM)
Masaki Fukunaga
(M)
Melanie E Garrett
(ME)
Tian Ge
(T)
Sudheer Giddaluru
(S)
Aaron L Goldman
(AL)
Nynke A Groenewold
(NA)
Dominik Grotegerd
(D)
Tiril P Gurholt
(TP)
Boris A Gutman
(BA)
Narelle K Hansell
(NK)
Mathew A Harris
(MA)
Marc B Harrison
(MB)
Courtney C Haswell
(CC)
Michael Hauser
(M)
Stefan Herms
(S)
Dirk J Heslenfeld
(DJ)
New Fei Ho
(NF)
David Hoehn
(D)
Per Hoffmann
(P)
Laurena Holleran
(L)
Martine Hoogman
(M)
Jouke-Jan Hottenga
(JJ)
Masashi Ikeda
(M)
Deborah Janowitz
(D)
Iris E Jansen
(IE)
Tianye Jia
(T)
Christiane Jockwitz
(C)
Ryota Kanai
(R)
Sherif Karama
(S)
Dalia Kasperaviciute
(D)
Tobias Kaufmann
(T)
Sinead Kelly
(S)
Masataka Kikuchi
(M)
Marieke Klein
(M)
Michael Knapp
(M)
Annchen R Knodt
(AR)
Bernd Krämer
(B)
Max Lam
(M)
Thomas M Lancaster
(TM)
Phil H Lee
(PH)
Tristram A Lett
(TA)
Lindsay B Lewis
(LB)
Iscia Lopes-Cendes
(I)
Michelle Luciano
(M)
Fabio Macciardi
(F)
Andre F Marquand
(AF)
Samuel R Mathias
(SR)
Tracy R Melzer
(TR)
Yuri Milaneschi
(Y)
Nazanin Mirza-Schreiber
(N)
Jose C V Moreira
(JCV)
Thomas W Mühleisen
(TW)
Bertram Müller-Myhsok
(B)
Pablo Najt
(P)
Soichiro Nakahara
(S)
Kwangsik Nho
(K)
Loes M Olde Loohuis
(LM)
Dimitri Papadopoulos Orfanos
(DP)
John F Pearson
(JF)
Toni L Pitcher
(TL)
Benno Pütz
(B)
Anjanibhargavi Ragothaman
(A)
Faisal M Rashid
(FM)
Ronny Redlich
(R)
Céline S Reinbold
(CS)
Jonathan Repple
(J)
Geneviève Richard
(G)
Brandalyn C Riedel
(BC)
Shannon L Risacher
(SL)
Cristiane S Rocha
(CS)
Nina Roth Mota
(NR)
Lauren Salminen
(L)
Arvin Saremi
(A)
Andrew J Saykin
(AJ)
Fenja Schlag
(F)
Lianne Schmaal
(L)
Peter R Schofield
(PR)
Rodrigo Secolin
(R)
Chin Yang Shapland
(CY)
Li Shen
(L)
Jean Shin
(J)
Elena Shumskaya
(E)
Ida E Sønderby
(IE)
Emma Sprooten
(E)
Lachlan T Strike
(LT)
Katherine E Tansey
(KE)
Alexander Teumer
(A)
Anbupalam Thalamuthu
(A)
Sophia I Thomopoulos
(SI)
Diana Tordesillas-Gutiérrez
(D)
Jessica A Turner
(JA)
Anne Uhlmann
(A)
Costanza Ludovica Vallerga
(CL)
Dennis van der Meer
(D)
Marjolein M J van Donkelaar
(MMJ)
Liza van Eijk
(L)
Theo G M van Erp
(TGM)
Neeltje E M van Haren
(NEM)
Daan van Rooij
(D)
Marie-José van Tol
(MJ)
Jan H Veldink
(JH)
Ellen Verhoef
(E)
Esther Walton
(E)
Mingyuan Wang
(M)
Yunpeng Wang
(Y)
Joanna M Wardlaw
(JM)
Wei Wen
(W)
Lars T Westlye
(LT)
Christopher D Whelan
(CD)
Stephanie H Witt
(SH)
Katharina Wittfeld
(K)
Christiane Wolf
(C)
Thomas Wolfers
(T)
Clarissa L Yasuda
(CL)
Dario Zaremba
(D)
Zuo Zhang
(Z)
Alyssa H Zhu
(AH)
Marcel P Zwiers
(MP)
Eric Artiges
(E)
Amelia A Assareh
(AA)
Rosa Ayesa-Arriola
(R)
Aysenil Belger
(A)
Christine L Brandt
(CL)
Gregory G Brown
(GG)
Sven Cichon
(S)
Joanne E Curran
(JE)
Gareth E Davies
(GE)
Franziska Degenhardt
(F)
Bruno Dietsche
(B)
Srdjan Djurovic
(S)
Colin P Doherty
(CP)
Ryan Espiritu
(R)
Daniel Garijo
(D)
Yolanda Gil
(Y)
Penny A Gowland
(PA)
Robert C Green
(RC)
Alexander N Häusler
(AN)
Walter Heindel
(W)
Beng-Choon Ho
(BC)
Wolfgang U Hoffmann
(WU)
Florian Holsboer
(F)
Georg Homuth
(G)
Norbert Hosten
(N)
Clifford R Jack
(CR)
MiHyun Jang
(M)
Andreas Jansen
(A)
Knut Kolskår
(K)
Sanne Koops
(S)
Axel Krug
(A)
Kelvin O Lim
(KO)
Jurjen J Luykx
(JJ)
Daniel H Mathalon
(DH)
Karen A Mather
(KA)
Venkata S Mattay
(VS)
Sarah Matthews
(S)
Jaqueline Mayoral Van Son
(JMV)
Sarah C McEwen
(SC)
Ingrid Melle
(I)
Derek W Morris
(DW)
Bryon A Mueller
(BA)
Matthias Nauck
(M)
Jan E Nordvik
(JE)
Markus M Nöthen
(MM)
Daniel S O'Leary
(DS)
Nils Opel
(N)
Marie -Laure Paillère Martinot
(M-P)
G Bruce Pike
(GB)
Adrian Preda
(A)
Erin B Quinlan
(EB)
Varun Ratnakar
(V)
Simone Reppermund
(S)
Vidar M Steen
(VM)
Fábio R Torres
(FR)
Dick J Veltman
(DJ)
James T Voyvodic
(JT)
Robert Whelan
(R)
Tonya White
(T)
Hidenaga Yamamori
(H)
Marina K M Alvim
(MKM)
David Ames
(D)
Tim J Anderson
(TJ)
Ole A Andreassen
(OA)
Alejandro Arias-Vasquez
(A)
Mark E Bastin
(ME)
Bernhard T Baune
(BT)
John Blangero
(J)
Dorret I Boomsma
(DI)
Henry Brodaty
(H)
Han G Brunner
(HG)
Randy L Buckner
(RL)
Jan K Buitelaar
(JK)
Juan R Bustillo
(JR)
Wiepke Cahn
(W)
Vince Calhoun
(V)
Xavier Caseras
(X)
Svenja Caspers
(S)
Gianpiero L Cavalleri
(GL)
Fernando Cendes
(F)
Aiden Corvin
(A)
Benedicto Crespo-Facorro
(B)
John C Dalrymple-Alford
(JC)
Udo Dannlowski
(U)
Eco J C de Geus
(EJC)
Ian J Deary
(IJ)
Norman Delanty
(N)
Chantal Depondt
(C)
Sylvane Desrivières
(S)
Gary Donohoe
(G)
Thomas Espeseth
(T)
Guillén Fernández
(G)
Simon E Fisher
(SE)
Herta Flor
(H)
Andreas J Forstner
(AJ)
Clyde Francks
(C)
Barbara Franke
(B)
David C Glahn
(DC)
Randy L Gollub
(RL)
Hans J Grabe
(HJ)
Oliver Gruber
(O)
Asta K Håberg
(AK)
Ahmad R Hariri
(AR)
Catharina A Hartman
(CA)
Ryota Hashimoto
(R)
Andreas Heinz
(A)
Manon H J Hillegers
(MHJ)
Pieter J Hoekstra
(PJ)
Avram J Holmes
(AJ)
L Elliot Hong
(LE)
William D Hopkins
(WD)
Hilleke E Hulshoff Pol
(HE)
Terry L Jernigan
(TL)
Erik G Jönsson
(EG)
René S Kahn
(RS)
Martin A Kennedy
(MA)
Tilo T J Kircher
(TTJ)
Peter Kochunov
(P)
John B J Kwok
(JBJ)
Stephanie Le Hellard
(SL)
Nicholas G Martin
(NG)
Jean -Luc Martinot
(J-)
Colm McDonald
(C)
Katie L McMahon
(KL)
Andreas Meyer-Lindenberg
(A)
Rajendra A Morey
(RA)
Lars Nyberg
(L)
Jaap Oosterlaan
(J)
Roel A Ophoff
(RA)
Tomáš Paus
(T)
Zdenka Pausova
(Z)
Brenda W J H Penninx
(BWJH)
Tinca J C Polderman
(TJC)
Danielle Posthuma
(D)
Marcella Rietschel
(M)
Joshua L Roffman
(JL)
Laura M Rowland
(LM)
Perminder S Sachdev
(PS)
Philipp G Sämann
(PG)
Gunter Schumann
(G)
Kang Sim
(K)
Sanjay M Sisodiya
(SM)
Jordan W Smoller
(JW)
Iris E Sommer
(IE)
Beate St Pourcain
(BS)
Dan J Stein
(DJ)
Arthur W Toga
(AW)
Julian N Trollor
(JN)
Nic J A Van der Wee
(NJA)
Dennis van 't Ent
(D)
Henry Völzke
(H)
Henrik Walter
(H)
Bernd Weber
(B)
Daniel R Weinberger
(DR)
Margaret J Wright
(MJ)
Juan Zhou
(J)
Jason L Stein
(JL)
Paul M Thompson
(PM)
Sarah E Medland
(SE)
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