Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
09
04
2020
accepted:
08
09
2020
revised:
03
08
2020
pubmed:
24
9
2020
medline:
12
6
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
We investigate the role of the mitochondrion, an organelle highly sensitive to environmental agents, in the influence of prenatal air pollution exposure on neurodevelopment and behavior in 96 children with autism spectrum disorder (ASD) [45 with neurodevelopmental regression (NDR); 76% Male; mean (SD) age 10 y 9 m (3 y 9 m)]. Mitochondrial function was assessed using the Seahorse XFe96 in fresh peripheral blood mononuclear cells. Second and third trimester average and maximal daily exposure to fine air particulate matter of diameter ≤2.5 µm (PM
Identifiants
pubmed: 32963337
doi: 10.1038/s41380-020-00885-2
pii: 10.1038/s41380-020-00885-2
pmc: PMC8159748
doi:
Substances chimiques
Air Pollutants
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1561-1577Références
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