In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2.
chlorpheniramine maleate
covid-19
nasal spray
sars-cov-2
virucidal
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
17 Sep 2020
17 Sep 2020
Historique:
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
24
9
2020
Statut:
epublish
Résumé
Background The initial global outbreak of the novel coronavirus disease 2019 (COVID-2019) pandemic, which is responsible for the severe acute respiratory syndrome 2 (SARS-CoV-2), shares similarities with the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) and behaves similarly to influenza with a high intranasal viral load. The genome sequence of COVID-19 opened the opportunity for multiple in vitro and clinical trials, but we still do not have a clear path to treatment. Chlorpheniramine maleate (CPM) is a safe and effective antihistamine with potent antiviral activity against various strains of influenza A/B, thus suggesting that CPM has broad antiviral activity. We tested the virucidal potential of CPM in a nasal spray composition currently in development as an anti-allergy medication. Methods The virucidal activity of CPM was tested using viral stock of SARS-CoV-2, USA-WA1/2020 strain in Vero 76 infected cells. The endpoint titer 50% cell culture infection dose (CCID
Identifiants
pubmed: 32963923
doi: 10.7759/cureus.10501
pmc: PMC7500730
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10501Informations de copyright
Copyright © 2020, Westover et al.
Déclaration de conflit d'intérêts
Dr. Ferrer has a patent pending for the intranasal formulation with chlorpheniramine.
Références
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Biopharm Drug Dispos. 1997 May;18(4):335-46
pubmed: 9158881
Cell. 2020 Jul 23;182(2):429-446.e14
pubmed: 32526206
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
Trans R Soc Trop Med Hyg. 1998 Jan-Feb;92(1):77-81
pubmed: 9692161
Front Microbiol. 2018 Nov 06;9:2643
pubmed: 30459739
Br J Dis Chest. 1983 Apr;77(2):113-22
pubmed: 6347231