Cigarette-related cadmium and environmental pollution exposure are reflected in airway ultrafine particle content.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
07
01
2020
accepted:
15
06
2020
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
24
9
2020
Statut:
epublish
Résumé
Particulate matter (PM) and cigarette-related cadmium exposure increases inflammation and smokers' susceptibility to developing lung diseases. The majority of inhaled metals are attached to the surface of ultrafine particles (UFPs). A low inhaled UFP content in exhaled breath condensate (EBC) reflects a high inflammatory status of airways. EBC was collected from 58 COPD patients and 40 healthy smokers and nonsmokers. Participants underwent spirometry, diffusion capacity, EBC and blood sampling. Environmental pollution data were collected from monitoring stations. UFPs were measured in EBC and serum, and cadmium content was quantified. Subjects with low UFP concentrations in EBC (<0.18×10 Low UFP concentration in EBC is an indicator of high-level PM exposure. High cadmium levels in EBC among smokers and the association between cadmium and UFP content in EBC among COPD patients indicate cadmium lung toxicity.
Identifiants
pubmed: 32963996
doi: 10.1183/23120541.00361-2019
pii: 00361-2019
pmc: PMC7487350
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: E. Fireman Klein has nothing to disclose. Conflict of interest: Y. Adir has nothing to disclose. Conflict of interest: E. Fireman has nothing to disclose. Conflict of interest: A. Kessel has nothing to disclose.
Références
Eur Respir J. 2015 Jan;45(1):38-50
pubmed: 25193994
J Breath Res. 2018 Feb 07;12(2):027112
pubmed: 29244031
Curr Environ Health Rep. 2018 Mar;5(1):70-76
pubmed: 29383658
N Engl J Med. 2017 Jun 29;376(26):2513-2522
pubmed: 28657878
Occup Environ Med. 2001 Mar;58(3):211-6, 199
pubmed: 11171936
Eur Respir Rev. 2018 Mar 28;27(147):
pubmed: 29592863
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1487-1495
pubmed: 30785782
Eur Respir J. 2009 Sep;34(3):648-54
pubmed: 19720809
Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88
pubmed: 31613151
Eur Respir J. 2005 Sep;26(3):523-48
pubmed: 16135737
Thorax. 2004 Mar;59(3):194-8
pubmed: 14985551
Nat Commun. 2019 Mar 15;10(1):1236
pubmed: 30874557
Inhal Toxicol. 2009 Jan;21(1):1-31
pubmed: 18803063
J Allergy Clin Immunol. 2016 Aug;138(2):386-96
pubmed: 27130856
ERJ Open Res. 2016 Mar 17;2(1):
pubmed: 27730180
Lancet. 2018 Jan 27;391(10118):339-349
pubmed: 29221643
Eur Respir J. 2014 Jan;43(1):250-63
pubmed: 23471349
J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):163-70
pubmed: 24002489
Environ Pollut. 2019 May;248:1-9
pubmed: 30763815
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
Exp Ther Med. 2019 Oct;18(4):2503-2511
pubmed: 31572502
Int J Epidemiol. 2012 Feb;41(1):24-32
pubmed: 22296988
Int J Environ Res Public Health. 2013 Dec 20;11(1):202-17
pubmed: 24452255
Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):415-423
pubmed: 27956251
Epidemiology. 2015 May;26(3):310-20
pubmed: 25710246
Circulation. 2018 Apr 17;137(16):1688-1697
pubmed: 29237717
Int J Chron Obstruct Pulmon Dis. 2016 May 11;11:1005-13
pubmed: 27274222
Lancet. 2016 Oct 15;388(10054):1939-1951
pubmed: 27751401
N Engl J Med. 2007 Dec 6;357(23):2348-58
pubmed: 18057337
Respiration. 2015;90(1):74-84
pubmed: 26068137
Environ Int. 2018 Dec;121(Pt 1):610-619
pubmed: 30312964
Int J Hyg Environ Health. 2016 Jan;219(1):40-7
pubmed: 26306830
ScientificWorldJournal. 2012;2012:729430
pubmed: 22489199
Int J Chron Obstruct Pulmon Dis. 2019 Mar 01;14:557-564
pubmed: 30880945
Environ Health. 2017 Jun 19;16(1):64
pubmed: 28629362
Exp Mol Med. 2020 Mar;52(3):329-337
pubmed: 32203100
Int J Environ Health Res. 2015;25(1):67-80
pubmed: 24670229
J Allergy Clin Immunol. 2018 Mar;141(3):833-844
pubmed: 29519450
Int J Chron Obstruct Pulmon Dis. 2009;4:233-43
pubmed: 19554194
Am J Med Sci. 2009 Oct;338(4):273-9
pubmed: 19726973