Association of germline variation with the survival of women with

Breast cancer Cancer genetics Genome-wide association studies

Journal

NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891

Informations de publication

Date de publication:
2020
Historique:
received: 21 01 2020
accepted: 11 08 2020
entrez: 23 9 2020
pubmed: 24 9 2020
medline: 24 9 2020
Statut: epublish

Résumé

Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline pathogenic variants in

Identifiants

pubmed: 32964118
doi: 10.1038/s41523-020-00185-6
pii: 185
pmc: PMC7483417
doi:

Types de publication

Journal Article

Langues

eng

Pagination

44

Subventions

Organisme : Cancer Research UK
ID : 11174
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : HHSN268201200008C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200008I
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148065
Pays : United States

Informations de copyright

© The Author(s) 2020.

Déclaration de conflit d'intérêts

Competing interestsH.N. has received an honorarium from AstraZeneca. The other authors declare no competing interests.

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Auteurs

Taru A Muranen (TA)

University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland.

Sofia Khan (S)

University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland.
University of Turku and Åbo Akademi University, Turku Bioscience Centre, Turku, Finland.

Rainer Fagerholm (R)

University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland.

Kristiina Aittomäki (K)

University of Helsinki, Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland.

Julie M Cunningham (JM)

Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN USA.

Joe Dennis (J)

University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.

Goska Leslie (G)

University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.

Lesley McGuffog (L)

University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.

Michael T Parsons (MT)

QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD Australia.

Jacques Simard (J)

CHU de Quebec Research Center, Genomics Center, Québec City, QC Canada.

Susan Slager (S)

Mayo Clinic, Department of Health Sciences Research, Rochester, MN USA.

Penny Soucy (P)

CHU de Quebec Research Center, Genomics Center, Québec City, QC Canada.

Douglas F Easton (DF)

University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.

Marc Tischkowitz (M)

McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC Canada.
University of Cambridge, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK.

Amanda B Spurdle (AB)

QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD Australia.

Rita K Schmutzler (RK)

Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.

Barbara Wappenschmidt (B)

Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.

Eric Hahnen (E)

Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.

Maartje J Hooning (MJ)

Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.

Christian F Singer (CF)

Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria.

Gabriel Wagner (G)

Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria.

Mads Thomassen (M)

Odense University Hospital, Department of Clinical Genetics, Odence C, Denmark.

Inge Sokilde Pedersen (IS)

Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark.
Aalborg University, Dept of Clinical Medicine, Aalborg, Denmark.

Susan M Domchek (SM)

Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA USA.

Katherine L Nathanson (KL)

Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA USA.

Conxi Lazaro (C)

ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Molecular Diagnostic Unit, Hereditary Cancer Program, Barcelona, Spain.

Caroline Maria Rossing (CM)

Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark.

Irene L Andrulis (IL)

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON Canada.
University of Toronto, Department of Molecular Genetics, Toronto, ON Canada.

Manuel R Teixeira (MR)

Portuguese Oncology Institute, Department of Genetics, Porto, Portugal.
University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal.

Paul James (P)

Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC Australia.
The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC Australia.

Judy Garber (J)

Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA USA.

Jeffrey N Weitzel (JN)

City of Hope, Clinical Cancer Genomics, Duarte, CA USA.

Anna Jakubowska (A)

Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland.
Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland.

Drakoulis Yannoukakos (D)

National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece.

Esther M John (EM)

Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA USA.

Melissa C Southey (MC)

Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC Australia.
The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC Australia.

Marjanka K Schmidt (MK)

The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Division of Psychosocial Research and Epidemiology, Amsterdam, The Netherlands.

Antonis C Antoniou (AC)

University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.

Georgia Chenevix-Trench (G)

QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD Australia.

Carl Blomqvist (C)

University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, Finland.
Örebro University Hospital, Department of Oncology, Örebro, Sweden.

Heli Nevanlinna (H)

University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland.

Classifications MeSH