Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take.
cancer metabolism
diet
microenvironment
nutrients
tumor heterogeneity
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 10 2020
05 10 2020
Historique:
received:
14
04
2020
revised:
08
07
2020
accepted:
04
09
2020
pubmed:
24
9
2020
medline:
28
4
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
Nutrients are indispensable resources that provide the macromolecular building blocks and energy requirements for sustaining cell growth and survival. Cancer cells require several key nutrients to fulfill their changing metabolic needs as they progress through stages of development. Moreover, both cell-intrinsic and microenvironment-influenced factors determine nutrient dependencies throughout cancer progression-for which a comprehensive characterization remains incomplete. In addition to the widely studied role of genetic alterations driving cancer metabolism, nutrient use in cancer tissue may be affected by several factors including the following: (i) diet, the primary source of bodily nutrients which influences circulating metabolite levels; (ii) tissue of origin, which can influence the tumor's reliance on specific nutrients to support cell metabolism and growth; (iii) local microenvironment, which dictates the accessibility of nutrients to tumor cells; (iv) tumor heterogeneity, which promotes metabolic plasticity and adaptation to nutrient demands; and (v) functional demand, which intensifies metabolic reprogramming to fuel the phenotypic changes required for invasion, growth, or survival. Here, we discuss the influence of these factors on nutrient metabolism and dependence during various steps of tumor development and progression.
Identifiants
pubmed: 32964587
doi: 10.15252/embr.202050635
pmc: PMC7534637
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e50635Subventions
Organisme : EC|H2020|H2020 Priority Excellent Science|H2020 Marie Skłodowska-Curie Actions (MSCA)
ID : 839896
Organisme : EC|H2020|H2020 Priority Excellent Science|H2020 European Research Council (ERC)
ID : 771486
Organisme : Boehringer Ingelheim Fonds (BIF)
Organisme : Fonds Wetenschappelijk Onderzoek (FWO)
ID : G098120N
Organisme : Fonds Wetenschappelijk Onderzoek (FWO)
ID : G088318N
Organisme : Fonds Baillet Latour
Informations de copyright
© 2020 The Authors.
Références
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nat Commun. 2015 Mar 11;6:6528
pubmed: 25758642
Science. 2018 Jun 1;360(6392):962-963
pubmed: 29853672
Biochim Biophys Acta. 2011 Jun;1807(6):726-34
pubmed: 21692241
Sci Adv. 2019 Jan 02;5(1):eaau7314
pubmed: 30613774
Nature. 2018 Aug;560(7719):499-503
pubmed: 30051890
Science. 2018 May 25;360(6391):
pubmed: 29798856
Mol Cell. 2020 Jan 16;77(2):213-227.e5
pubmed: 31735641
Nat Med. 2017 Feb;23(2):235-241
pubmed: 28024083
Pharmacol Res. 2019 Dec;150:104500
pubmed: 31629092
Acta Pharm Sin B. 2020 Jan;10(1):79-90
pubmed: 31993308
Cell Metab. 2019 Jun 4;29(6):1410-1421.e4
pubmed: 30905671
Nature. 2016 Aug 25;536(7617):479-83
pubmed: 27509858
Cell Metab. 2018 May 01;27(5):947-949
pubmed: 29719230
BMC Cancer. 2018 Apr 27;18(1):476
pubmed: 29699509
Biol Cell. 2015 Aug;107(8):251-72
pubmed: 25913226
Nat Commun. 2017 May 11;8:15267
pubmed: 28492237
Cell. 2017 Feb 9;168(4):670-691
pubmed: 28187288
Cell Metab. 2019 Sep 3;30(3):594-606.e3
pubmed: 31257152
Nature. 2012 Feb 15;482(7386):529-33
pubmed: 22343890
Nature. 2019 Feb;566(7744):403-406
pubmed: 30728499
Nutrients. 2020 Jan 01;12(1):
pubmed: 31906264
Mol Cell. 2020 Jan 2;77(1):120-137.e9
pubmed: 31733993
Wiley Interdiscip Rev Syst Biol Med. 2018 Jan;10(1):
pubmed: 28857478
Science. 2013 Feb 1;339(6119):543-8
pubmed: 23239622
Biochim Biophys Acta. 2010 Jan;1805(1):105-17
pubmed: 19931353
Breast Cancer Res. 2011 Aug 11;13(4):R78
pubmed: 21834963
J Exp Clin Cancer Res. 2018 Jun 28;37(1):127
pubmed: 29954422
Nature. 2019 Apr;568(7750):117-121
pubmed: 30814728
Nat Cell Biol. 2020 Jul;22(7):779-790
pubmed: 32451440
J Hepatol. 2018 Aug;69(2):385-395
pubmed: 29572095
Cell Metab. 2016 Mar 8;23(3):517-28
pubmed: 26853747
Clin Chem. 2017 Mar;63(3):700-713
pubmed: 28007957
Cell Rep. 2020 Jun 23;31(12):107806
pubmed: 32579932
Cancer. 1966 Dec;19(12):1813-9
pubmed: 4959138
Cell. 2019 Jul 11;178(2):316-329.e18
pubmed: 31257023
Biochem J. 2018 May 9;475(9):1611-1634
pubmed: 29743249
Cell Metab. 2012 Jun 6;15(6):827-37
pubmed: 22682223
Nat Cell Biol. 2015 Dec;17(12):1556-68
pubmed: 26595383
Cell. 2017 Feb 9;168(4):657-669
pubmed: 28187287
J Neurosci. 2003 Jul 2;23(13):5928-35
pubmed: 12843297
Nature. 2014 Oct 23;514(7523):508-12
pubmed: 25174708
Cell Rep. 2016 Oct 11;17(3):837-848
pubmed: 27732858
Cell Metab. 2017 Nov 7;26(5):778-787.e5
pubmed: 28988825
Cancer Discov. 2019 Dec;9(12):1708-1719
pubmed: 31554641
Nat Med. 2011 Oct 30;17(11):1498-503
pubmed: 22037646
Cell Commun Signal. 2019 Feb 28;17(1):19
pubmed: 30819189
J Nucl Med. 2017 Oct;58(10):1574-1579
pubmed: 28596159
Environ Health Perspect. 1984 Apr;55:149-58
pubmed: 6376097
Cancer Cell. 2020 Feb 10;37(2):141-142
pubmed: 32049042
J Cell Sci. 2016 Sep 15;129(18):3367-73
pubmed: 27635066
Dev Cell. 2019 May 6;49(3):361-374
pubmed: 31063755
Nat Med. 2017 Jan;23(1):120-127
pubmed: 27869804
BMC Cancer. 2016 Jun 10;16:360
pubmed: 27282289
Mol Cancer. 2017 Feb 28;16(1):51
pubmed: 28245869
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9533-9542
pubmed: 31019077
Prostaglandins Other Lipid Mediat. 2016 Dec;127:9-13
pubmed: 27913146
Nat Commun. 2016 Oct 10;7:13041
pubmed: 27721378
Sci Transl Med. 2015 Oct 7;7(308):308re8
pubmed: 26446958
Elife. 2019 Apr 16;8:
pubmed: 30990168
Nat Genet. 2018 Feb;50(2):206-218
pubmed: 29335545
Nat Chem Biol. 2016 Jul;12(7):482-9
pubmed: 27159581
J Exp Med. 1963 Jul;118:99-120
pubmed: 14015821
Cell Rep. 2016 May 10;15(6):1161-74
pubmed: 27134168
Antioxid Redox Signal. 2014 Oct 10;21(11):1605-19
pubmed: 24762207
J Agric Food Chem. 2015 Sep 9;63(35):7873-84
pubmed: 26262841
Cell. 2018 Jan 11;172(1-2):205-217.e12
pubmed: 29307488
BMC Cancer. 2014 May 21;14:352
pubmed: 24886074
Nat Cell Biol. 2016 Oct;18(10):1090-101
pubmed: 27617932
NMR Biomed. 2012 Nov;25(11):1234-44
pubmed: 22419606
Nat Commun. 2016 Apr 29;7:11457
pubmed: 27126896
Nat Rev Cancer. 2018 Feb;18(2):128-134
pubmed: 29326430
Front Immunol. 2019 Jul 09;10:1565
pubmed: 31354721
Cell. 2017 Apr 06;169(2):258-272.e17
pubmed: 28388410
J Exp Clin Cancer Res. 2018 Dec 4;37(1):302
pubmed: 30514331
Cell Rep. 2018 Jul 3;24(1):47-55
pubmed: 29972790
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6
pubmed: 25489084
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442
pubmed: 31000598
Cell Rep. 2020 Jan 21;30(3):714-724.e5
pubmed: 31968248
Nature. 2016 Mar 3;531(7592):110-3
pubmed: 26909577
BMC Cancer. 2015 Oct 05;15:652
pubmed: 26438237
Cell Rep. 2016 May 10;15(6):1144-60
pubmed: 27134166
Oncogene. 2017 Apr;36(15):2074-2084
pubmed: 27748760
Front Oncol. 2019 Mar 12;9:140
pubmed: 30915275
Front Oncol. 2019 Apr 24;9:219
pubmed: 31069166
Cancer Res. 1962 Jun;22:581-8
pubmed: 13874819
Nature. 2020 Jan;577(7788):115-120
pubmed: 31853067
Cell Metab. 2018 Nov 6;28(5):793-800.e2
pubmed: 30146487
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr. 1958;196(6):611-26
pubmed: 13534602
Cell. 2015 Feb 26;160(5):963-976
pubmed: 25723170
Cancers (Basel). 2019 May 16;11(5):
pubmed: 31100816
Mol Metab. 2020 Mar;33:48-66
pubmed: 31395464
Nature. 2015 Nov 12;527(7577):186-91
pubmed: 26466563
Chin J Cancer. 2016 Feb 12;35:19
pubmed: 26873579
Cancer Res. 2012 Oct 1;72(19):5130-40
pubmed: 22850421
Elife. 2017 Aug 15;6:
pubmed: 28826492
BMJ. 2017 Feb 28;356:j477
pubmed: 28246088
Mol Metab. 2020 Mar;33:83-101
pubmed: 31668988
Semin Cancer Biol. 2018 Dec;53:265-281
pubmed: 30317036
Crit Rev Biochem Mol Biol. 2019 Jun;54(3):193-207
pubmed: 31162937
Cell Metab. 2012 Feb 8;15(2):157-70
pubmed: 22326218
Cell. 2014 Dec 18;159(7):1603-14
pubmed: 25525878
PLoS One. 2015 Jun 10;10(6):e0127407
pubmed: 26061868
Clin Cancer Res. 2016 May 15;22(10):2482-95
pubmed: 26631612
Trends Cancer. 2020 Jan;6(1):49-61
pubmed: 31952781
Cancer Discov. 2020 Sep;10(9):1352-1373
pubmed: 32571778
Nature. 2018 Feb 15;554(7692):378-381
pubmed: 29414946
Trends Neurosci. 2013 Oct;36(10):587-97
pubmed: 23968694
Science. 2018 Jan 5;359(6371):97-103
pubmed: 29097493
Nature. 2017 Apr 19;544(7650):372-376
pubmed: 28425994
Nature. 2019 Aug;572(7769):397-401
pubmed: 31367041
Nutr Res. 2016 Dec;36(12):1325-1334
pubmed: 27866828
Mol Carcinog. 2012 Nov;51(11):869-80
pubmed: 21919080
Nat Rev Microbiol. 2017 Aug;15(8):465-478
pubmed: 28529325
Nature. 2016 Apr 14;532(7598):255-8
pubmed: 27049945
Cell Rep. 2017 Nov 7;21(6):1521-1533
pubmed: 29117558
Nature. 2009 Sep 3;461(7260):109-13
pubmed: 19693011
PeerJ. 2017 Sep 27;5:e3804
pubmed: 28970966
Cancer Res. 2016 Jul 15;76(14):4136-48
pubmed: 27206847
J Neurochem. 2009 May;109 Suppl 1:46-54
pubmed: 19393008
Genes Cells. 2016 Dec;21(12):1320-1332
pubmed: 27813205
Cell. 2018 Aug 9;174(4):843-855.e19
pubmed: 30017245
J Cancer. 2019 Aug 7;10(19):4574-4587
pubmed: 31528221
Cell Metab. 2016 May 10;23(5):867-80
pubmed: 27133130
Oncoimmunology. 2019 Apr 3;8(7):1591878
pubmed: 31143510
Nat Cell Biol. 2015 Feb;17(2):183-94
pubmed: 25621950
Nature. 2017 Jan 5;541(7635):41-45
pubmed: 27974793
Cancer Res. 2013 Jul 1;73(13):3811-6
pubmed: 23794703
EMBO Rep. 2020 Oct 5;21(10):e50635
pubmed: 32964587
Nat Rev Cancer. 2017 Apr;17(4):239-253
pubmed: 28256574
Am J Physiol. 1974 Apr;226(4):867-73
pubmed: 4823047
Nat Commun. 2019 Aug 21;10(1):3763
pubmed: 31434891
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
J Biol Chem. 2015 Jun 12;290(24):14811-25
pubmed: 25897074
Science. 2018 Jan 5;359(6371):91-97
pubmed: 29097494
Nat Rev Cancer. 2019 Nov;19(11):651-661
pubmed: 31530936
Cell. 2017 Dec 14;171(7):1611-1624.e24
pubmed: 29198524
Biosci Rep. 2017 Dec 12;37(6):
pubmed: 29026008
J Hepatol. 2016 Sep;65(3):579-88
pubmed: 27261415
Cancer Sci. 2012 Apr;103(4):626-31
pubmed: 22212856
Cancer Res. 2016 Jan 1;76(1):24-9
pubmed: 26729790
Cell Rep. 2016 May 10;15(6):1134-43
pubmed: 27134180
Sci Transl Med. 2012 Jan 25;4(118):118ra11
pubmed: 22277968
Medicine (Baltimore). 2018 May;97(19):e0719
pubmed: 29742734
Clin Oncol (R Coll Radiol). 2007 Aug;19(6):385-96
pubmed: 17433637
Cell Death Differ. 2004 Jul;11 Suppl 1:S73-85
pubmed: 15105835
Cell Metab. 2019 Jul 2;30(1):36-50
pubmed: 31269428
Nat Med. 2018 Aug;24(8):1277-1289
pubmed: 29988129
Handb Exp Pharmacol. 2016;233:321-53
pubmed: 25912014
Annu Rev Physiol. 2019 Feb 10;81:403-428
pubmed: 30485759
J Nutr Biochem. 2017 Jan;39:126-133
pubmed: 27833053
Cell Metab. 2015 Oct 6;22(4):577-89
pubmed: 26365179
J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):62-71
pubmed: 27440950
Mol Metab. 2020 Mar;33:67-82
pubmed: 31926876
Oncotarget. 2016 Aug 2;7(31):50239-50257
pubmed: 27384484
Trends Cell Biol. 2018 Aug;28(8):673-684
pubmed: 29747903
Cell Metab. 2018 Feb 6;27(2):428-438.e5
pubmed: 29337136
Methods Enzymol. 2014;542:59-80
pubmed: 24862260
Science. 2016 Sep 9;353(6304):1161-5
pubmed: 27609895
Sci Rep. 2017 Jan 05;7:39975
pubmed: 28054593
Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2934-2939
pubmed: 28246332
Cancer Metab. 2016 Sep 16;4:18
pubmed: 27651895
Annu Rev Immunol. 2000;18:813-27
pubmed: 10837076
Science. 2019 Mar 22;363(6433):1345-1349
pubmed: 30898933
Oncogene. 2019 Jun;38(23):4637-4654
pubmed: 30742067
Diabetes. 2006 Apr;55(4):929-34
pubmed: 16567513
Nat Rev Cancer. 2020 Feb;20(2):107-124
pubmed: 31780785
Nat Rev Clin Oncol. 2016 Aug;13(8):504-15
pubmed: 26951041
Trends Biochem Sci. 2020 Mar;45(3):185-201
pubmed: 31955965
Semin Cancer Biol. 2017 Apr;43:74-89
pubmed: 28267587
Cancer Cell. 2020 Feb 10;37(2):168-182.e4
pubmed: 31983610
Semin Cancer Biol. 2015 Dec;35 Suppl:S244-S275
pubmed: 25865774
J Clin Invest. 2015 Feb;125(2):687-98
pubmed: 25607840
Mol Cancer. 2009 Jun 26;8:41
pubmed: 19558692
Nat Commun. 2018 Nov 8;9(1):4681
pubmed: 30409977
Int J Obes (Lond). 2016 Oct;40(10):1582-1590
pubmed: 27200507
Cell. 2017 Oct 5;171(2):358-371.e9
pubmed: 28985563
Microbiome. 2020 May 28;8(1):74
pubmed: 32466801
Cancer Res. 2015 Feb 1;75(3):544-53
pubmed: 25644265
BMC Cancer. 2017 Nov 23;17(1):787
pubmed: 29169336
Nature. 2012 Jan 11;481(7382):506-10
pubmed: 22237025
Cell Metab. 2016 Nov 8;24(5):685-700
pubmed: 27829138
Breast Cancer Res. 2018 Jul 13;20(1):76
pubmed: 30005601
Cell Metab. 2011 Jul 6;14(1):131-42
pubmed: 21723511
Cell. 2016 Feb 11;164(4):681-94
pubmed: 26853473