Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.
Immune cells
Inflammation
Intradialytic exercise
Melatonin
Renal failure
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
02
05
2020
accepted:
07
09
2020
pubmed:
24
9
2020
medline:
23
7
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
The present study aimed to investigate the effects of melatonin (MEL) intake on systemic inflammation and immune responses during intradialytic exercise. Thirteen hemodialysis (HD) patients volunteered to participate in the current randomized-crossover study. Immunological responses were monitored in four HD sessions at different conditions: [Exercise (EX) + MEL], [EX + Placebo (PLA)], [Control (CON) + MEL] and [CON + PLA]. MEL (3 mg) or PLA was ingested 1 h before starting exercise or the equivalent time in CON condition. During all sessions, peripheral blood samples were collected to assess c-reactive protein, complete blood count, and immune cells phenotypes before HD (T0), immediately after exercise (T1) and 1 h after exercise (T2) or at corresponding times in the CON condition. HD therapy induced a significant decrease in natural killer (NK) (p = 0.001, d = 0.85; p < 0.001, d = 1.19, respectively) and CD8 This pilot study provides the first evidence that MEL intake alone or associated with intradialytic exercise displays potential immunoregulatory and anti-inflammatory effects. The combination of MEL with intradialytic exercise may be an appropriate anti-inflammatory therapy for HD patients.
Identifiants
pubmed: 32965623
doi: 10.1007/s11255-020-02643-3
pii: 10.1007/s11255-020-02643-3
doi:
Substances chimiques
Antioxidants
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
553-562Références
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