Inhibition of JC polyomavirus infectivity by the retrograde transport inhibitor Retro-2.1.
JCPyV
Retro-2
antiviral
polyomavirus
progressive multifocal leukoencephalopathy
retrograde
transport
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
20
02
2020
revised:
02
09
2020
accepted:
16
09
2020
pubmed:
24
9
2020
medline:
29
6
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
JC polyomavirus (JCPyV) is a common human pathogen that results in a chronic asymptomatic infection in healthy adults. Under conditions of immunosuppression, JCPyV spreads to the central nervous system and can cause the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), a disease for which there are no vaccines or antiviral therapies. Retro-2 is a previously identified small molecule inhibitor that was originally shown to block retrograde transport of toxins such as ricin toxin from endosomes to the Golgi apparatus and endoplasmic reticulum (ER), and Retro-2.1 is a chemical analog of Retro-2 that has been shown to inhibit ricin intoxication of cells at low nanomolar concentrations. Retro-2 has previously been shown to prevent retrograde transport of JCPyV virions to the ER, but the effect of Retro-2.1 on JCPyV infectivity is unknown. Here it is shown that Retro-2.1 inhibits JCPyV with an EC
Identifiants
pubmed: 32965709
doi: 10.1111/1348-0421.12851
doi:
Substances chimiques
2-(((5-methyl-2-thienyl)methylene)amino)-N-phenylbenzamide
0
Benzamides
0
Thiophenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-791Subventions
Organisme : SUNY Cortland Faculty Research Program
Informations de copyright
© 2020 The Societies and John Wiley & Sons Australia, Ltd.
Références
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