The candidate vaccine strain Brucella ovis ∆abcBA is protective against Brucella melitensis infection in mice.
alginate encapsulation
brucellosis
immunization
interferon gamma
vaccine efficacy
Journal
Microbiology and immunology
ISSN: 1348-0421
Titre abrégé: Microbiol Immunol
Pays: Australia
ID NLM: 7703966
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
10
08
2020
revised:
08
09
2020
accepted:
18
09
2020
pubmed:
24
9
2020
medline:
23
6
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
Brucellosis is a major zoonotic disease, and Brucella melitensis is the species most often associated with human infection. Vaccination is the most efficient tool for controlling animal brucellosis, with a consequent decrease of incidence of human infections. Commercially available live attenuated vaccines provide some degree of protection, but retain residual pathogenicity to human and animals. In this study, Brucella ovis ∆abcBA (Bo∆abcBA), a live attenuated candidate vaccine strain, was tested in two formulations (encapsulated with alginate and alginate plus vitelline protein B [VpB]) to immunize mice against experimental challenge with B. melitensis strain 16M. One week after infection, livers and spleens of immunized mice had reduced numbers of the challenge strain B. melitensis 16M when compared with those of nonimmunized mice, with a reduction of approximately 1-log
Identifiants
pubmed: 32965738
doi: 10.1111/1348-0421.12850
doi:
Substances chimiques
Brucella Vaccine
0
Cytokines
0
Vaccines, Attenuated
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
730-736Subventions
Organisme : CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (307155/2018-8)
Organisme : FAPEMIG (Fundação de Amparo a Pesquisa do Estado de Minas Gerais, Brazil (CVZ-APQ-01591-14)
Organisme : CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil (23038.004535/2014-31)
Organisme : TAF was supported in part by a grant from NIH (R01 5 R01 HD084339-03)
Informations de copyright
© 2020 The Societies and John Wiley & Sons Australia, Ltd.
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