Design and Characterization of a Minimally Invasive Bipolar Electrode for Electroporation.
bipolar electrode
electroporation
minimally invasive
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
21 Sep 2020
21 Sep 2020
Historique:
received:
11
08
2020
revised:
18
09
2020
accepted:
18
09
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
25
9
2020
Statut:
epublish
Résumé
To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. A theoretical study was performed by using Comsol Multiphysics Simulations and pre-clinical tests have shown that the volume of ablated area is mainly influenced by applied voltage, while the diameter of the electrode had a lesser impact, making the goal of minimal-invasiveness possible. The conductive pole's length determined an increase of electroporated volume, while the insulated pole length inversely affects the electroporated volume size and shape; when the insulated pole length decreases, a more regular shape of the electric field is obtained. Moreover, the geometry of the electrode determined a different shape of the electroporated volume. A parenchymal damage in the liver of pigs due to irreversible electroporation protocol was observed. The minimally invasive bipolar electrode is able to treat an electroporated volume of about 10 mm in diameter by using a single-needle electrode. Moreover, the geometry and the electric characteristics can be selected to produce ellipsoidal ablation volumes.
Identifiants
pubmed: 32967343
pii: biology9090303
doi: 10.3390/biology9090303
pmc: PMC7563710
pii:
doi:
Types de publication
Journal Article
Langues
eng
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