Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry?
colon cancer
histology
interobserver variability
prognostic factor
tumor budding
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
21 Sep 2020
21 Sep 2020
Historique:
received:
15
08
2020
revised:
11
09
2020
accepted:
17
09
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
25
9
2020
Statut:
epublish
Résumé
The prognostic significance of tumor budding in colon cancer is unequivocally documented, and the recommendations of the International Tumor Budding Consensus Conference (ITBCC) are currently the accepted basis for its assessment. Up to now, it is unknown whether the general use of a supporting cytokeratin immunohistochemistry can improve the interobserver variability and prognostic significance. Six investigators with different levels of experience reassessed 229 cases of colon carcinoma (pT3/4, N+/-, M0) with a supporting cytokeratin immunohistochemistry. The results were compared to previous assessments, which have been performed only on H & E. Bd3 was significantly associated with the occurrence of distant metastases according to the assessments of three out of six investigators (
Identifiants
pubmed: 32967382
pii: diagnostics10090730
doi: 10.3390/diagnostics10090730
pmc: PMC7555133
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The study was supported by the Hermann-Egger Foundation with 3000 Euro. The Hermann-Egger Foundation is a social foundation, which supports mainly regional projects (incl. science) in Augsburg.
ID : -
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