Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests.
Anopheles
Malaria
Plasmodium falciparum
Plasmodium vivax
Rapid diagnostic test
Surveillance, Salivary biomarker
Transmission
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
23 Sep 2020
23 Sep 2020
Historique:
received:
12
06
2020
accepted:
15
09
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
30
4
2021
Statut:
epublish
Résumé
Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology. 1022 RDTs from two sub-Districts in Bangladesh (Alikadam and Kamalganj) were screened by qPCR for low-density Plasmodium falciparum and Plasmodium vivax infections, and by ELISA for Anopheles salivary gland antibodies as a marker for exposure to vectors. Concordance between RDT and qPCR was moderate. qPCR detected 31/1022 infections compared to 36/1022 diagnosed by RDT. Exposure to Anopheles was significantly higher in Kamalganj despite low transmission, which could be explained by low bed net use. Archived RDTs present a valuable source of antibodies for serological studies on exposure to vectors. In contrast, the benefit of screening archived RDTs to obtain a better estimate of clinical case numbers is moderate. Kamalganj could be prone to outbreaks.
Sections du résumé
BACKGROUND
BACKGROUND
Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology.
METHODS
METHODS
1022 RDTs from two sub-Districts in Bangladesh (Alikadam and Kamalganj) were screened by qPCR for low-density Plasmodium falciparum and Plasmodium vivax infections, and by ELISA for Anopheles salivary gland antibodies as a marker for exposure to vectors.
RESULTS
RESULTS
Concordance between RDT and qPCR was moderate. qPCR detected 31/1022 infections compared to 36/1022 diagnosed by RDT. Exposure to Anopheles was significantly higher in Kamalganj despite low transmission, which could be explained by low bed net use.
CONCLUSIONS
CONCLUSIONS
Archived RDTs present a valuable source of antibodies for serological studies on exposure to vectors. In contrast, the benefit of screening archived RDTs to obtain a better estimate of clinical case numbers is moderate. Kamalganj could be prone to outbreaks.
Identifiants
pubmed: 32967671
doi: 10.1186/s12936-020-03418-y
pii: 10.1186/s12936-020-03418-y
pmc: PMC7513508
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
345Subventions
Organisme : NCATS NIH HHS
ID : UL1TR002529
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : R21AI137891
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