The Effect of Systemic Tranexamic Acid on Hypercoagulable Complications and Perioperative Outcomes Following Three-Column Osteotomy for Adult Spinal Deformity.
3-column osteotomy
blood loss
complications
operative time
pedicle subtraction osteotomy
spinal deformity
tranexamic acid
vertebral column resection
Journal
Global spine journal
ISSN: 2192-5682
Titre abrégé: Global Spine J
Pays: England
ID NLM: 101596156
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
pubmed:
25
9
2020
medline:
25
9
2020
entrez:
24
9
2020
Statut:
ppublish
Résumé
Retrospective cohort study. Thoracolumbar 3-column osteotomy (3CO) is a powerful technique for correction of rigid adult spinal deformity (ASD). However, it can be associated with high-volume blood loss. This study seeks to investigate the efficacy and safety of tranexamic acid (TXA) in 3CO ASD patients. ASD patients who underwent 3CO from 2006 to 2019 were retrospectively reviewed. Outcomes were compared between TXA and non-TXA patients, and TXA doses. A total of 365 ASD patients were included: 181 TXA and 184 non-TXA. The mean age was 64.6 years and 60.5% were female. Operative time was shorter in the TXA group (295.6 vs 320.2 minutes, Systemic TXA use during 3CO for ASD surgery was not associated with decreased blood loss. TXA patients had shorter operative times, but this was driven mainly by surgeon experience on multivariate analysis. Routine use of TXA is safe and does not increase the incidence of hypercoagulable complications even at high doses.
Identifiants
pubmed: 32969252
doi: 10.1177/2192568220953812
pmc: PMC9121167
doi:
Types de publication
Journal Article
Langues
eng
Pagination
423-431Références
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