Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with
Adult
Aged
Anti-Bacterial Agents
/ therapeutic use
Breath Tests
Drug Administration Schedule
Drug Therapy, Combination
Esomeprazole
/ therapeutic use
Female
Helicobacter Infections
/ drug therapy
Helicobacter pylori
/ isolation & purification
Humans
Male
Middle Aged
Proton Pump Inhibitors
/ therapeutic use
Retrospective Studies
Treatment Outcome
Disease eradication
Esomeprazole
Helicobacter pylori
Proton pump inhibitors
Journal
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
ISSN: 2233-6869
Titre abrégé: Korean J Gastroenterol
Pays: Korea (South)
ID NLM: 101189416
Informations de publication
Date de publication:
25 09 2020
25 09 2020
Historique:
received:
19
05
2020
revised:
23
06
2020
accepted:
26
06
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
12
8
2021
Statut:
ppublish
Résumé
The rates of This study included 223 patients who were diagnosed with a The eradication rates were 67.7% (105/155; 95% CI 59.5-74.8%) in the 7-NEAC group and 80.9% (55/68; 95% CI 69.9-89.8%) in the 7-HEAC group (p=0.045). The adverse event rates were 5.8% (9/155) in the 7-NEAC group and 7.4% (5/68) in the 7-HEAC group (p=0.661). Multivariate analysis revealed being female (OR 2.08; 95% CI 1.15-3.76) to be associated with the failure of The eradication rate of the 7-HEAC group was higher than that of the 7-NEAC group. Nevertheless, more effective first-line therapies may be necessary for
Sections du résumé
Background/Aims
The rates of
Methods
This study included 223 patients who were diagnosed with a
Results
The eradication rates were 67.7% (105/155; 95% CI 59.5-74.8%) in the 7-NEAC group and 80.9% (55/68; 95% CI 69.9-89.8%) in the 7-HEAC group (p=0.045). The adverse event rates were 5.8% (9/155) in the 7-NEAC group and 7.4% (5/68) in the 7-HEAC group (p=0.661). Multivariate analysis revealed being female (OR 2.08; 95% CI 1.15-3.76) to be associated with the failure of
Conclusions
The eradication rate of the 7-HEAC group was higher than that of the 7-NEAC group. Nevertheless, more effective first-line therapies may be necessary for
Identifiants
pubmed: 32969362
pii: kjg.2020.76.3.142
doi: 10.4166/kjg.2020.76.3.142
doi:
Substances chimiques
Anti-Bacterial Agents
0
Proton Pump Inhibitors
0
Esomeprazole
N3PA6559FT
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM