Impact of an extended audit on identifying heart failure patients in general practice: baseline results of the OSCAR-HF pilot study.

Audit Clinical Diagnosis General practice Heart failure Quality of care Treatment

Journal

ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191

Informations de publication

Date de publication:
Dec 2020
Historique:
revised: 20 08 2020
received: 10 10 2019
accepted: 24 08 2020
pubmed: 25 9 2020
medline: 25 9 2020
entrez: 24 9 2020
Statut: ppublish

Résumé

Identifying heart failure (HF) patients in general practice is challenging, and little is known about the current quality of care. We implemented an extended audit from the electronic health records (EHRs) of general practitioners (GPs) to identify HF patients and investigate patient characteristics and quality of care. This study describes the baseline results of the OSCAR-HF pilot study in eight general practices (51 GPs) in Flanders, Belgium. This prospective trial ran for 6 months. Interventions included an extended audit, an N-terminal pro-B-type natriuretic peptide point-of-care test, and assistance of a specialist HF nurse. The extended audit searched on risk factors for HF, HF symptoms, signs, and medication in the GPs' EHR to generate a list of possible HF patients. GPs determined which patients had HF. Those HF patients constituted the OSCAR-HF study population. Each patient file was manually revised to extract biomarker measurements, echocardiography data, and quality indicators. An independent panel of experts assessed the validity of GPs' HF diagnoses. Feedback about the validity of the HF diagnosis was given to the GP. Out of 18 011 patients ≥ 40 years, we identified 310 patients with a registered HF diagnosis before the study start (HF prevalence: 1.7%). The extended audit led to a 74% increase in identified HF patients (n = 538, HF prevalence: 3.0%) with a mean age of 79 ± 11 years. The prevalence of HF with reduced ejection fraction (HFrEF) was 20% (n = 110). A high proportion of patients underwent echocardiography in the past 5 years (86%, n = 462). Natriuretic peptides were rarely available in patients' files (19%, n = 100). Medical specialists should improve communication about the HF diagnosis because a specialist diagnosis was present in only 225 patients (42%) while 67% (n = 359) of the HF diagnoses were judged objectified by a panel of experts. Assigning a diagnosis of HF was particularly difficult in HF patients with preserved EF (HFpEF). HFrEF treatment rates with renin-angiotensin-aldosterone system blockers (84%, n = 92) and beta-blockers (86%, n = 94) were very good; however, target doses were hardly reached (34% and 14%, respectively). This study highlighted the need to improve case finding for HF in general practice and showed that an extended audit in the GPs' EHR was a successful strategy to do so. To improve the quality of HF care in general practice, specific strategies are needed to diagnose HFpEF and to reach target doses of disease-modifying drugs in HFrEF patients.

Identifiants

pubmed: 32969599
doi: 10.1002/ehf2.12990
pmc: PMC7754725
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3950-3961

Subventions

Organisme : Viviane Conraads Price
Organisme : Novartis Pharma
ID : S54755
Organisme : Department of Cardiovascular Diseases, ZOL Genk
Organisme : Department of Public Health and Primary Care (KUL)
Organisme : Department of Cardiovascular Diseases, UZ Leuven (KUL)

Informations de copyright

© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

Références

Cleland JG, Cohen-Solal A, Aguilar JC, Dietz R, Eastaugh J, Follath F, Freemantle N, Gavazzi A, van Gilst WH, Hobbs FD, Korewicki J, Madeira HC, Preda I, Swedberg K, Widimsky J. Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey. Lancet 2002; 360: 1631-1639.
Stork S, Handrock R, Jacob J, Walker J, Calado F, Lahoz R, Hupfer S, Klebs S. Treatment of chronic heart failure in Germany: a retrospective database study. Clinical rese cardio: official j German Cardiac Soc 2017; 106: 923-932.
Smeets M, Henrard S, Aertgeerts B, Cools F, Janssens S, Vaes B. Methods to identify heart failure patients in general practice and their impact on patient characteristics: a systematic review. Int J Cardiol 2018; 257: 199-206.
de Maeseneer J, Roberts RG, Demarzo M, Heath I, Sewankambo N, Kidd MR, van Weel C, Egilman D, Boelen C, Willems S. Tackling NCDs: a different approach is needed. Lancet 2012; 379: 1860-1861.
Huntley AL, Johnson R, King A, Morris RW, Purdy S. Does case management for patients with heart failure based in the community reduce unplanned hospital admissions? A syste rev meta-analysis BMJ Open 2016; 6: e010933.
Fonseca C. Diagnosis of heart failure in primary care. Heart Fail Rev 2006; 11: 95-107.
Smeets M, Degryse J, Aertgeerts B, Janssens S, Adriaensen W, Mathei C, van Pottelbergh G, Wallemacq P, Vanoverschelde JL, Vaes B. General practitioners' judgement of chronic heart failure in the oldest old: Insights from the BELFRAIL study. Int J Cardiol 2015; 191: 120-127.
Valk MJ, Mosterd A, Broekhuizen BD, Zuithoff NP, Landman MA, Hoes AW, Rutten FH. Overdiagnosis of heart failure in primary care: a cross-sectional study. The British J General Prac: J Royal Col General Practi 2016; 66: e587-e592.
Smeets M, Vaes B, Mamouris P, van den Akker M, van Pottelbergh G, Goderis G, Janssens S, Aertgeerts B, Henrard S. Burden of heart failure in Flemish general practices: a registry-based study in the Intego database. BMJ Open 2019; 9: e022972.
Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003; 289: 194-202.
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016; 18: 891-975.
Hysong SJ. Meta-analysis: audit and feedback features impact effectiveness on care quality. Med Care 2009; 47: 356-363.
Ivers NM, Grimshaw JM, Jamtvedt G, Flottorp S, O'Brien MA, French SD, Young J, Odgaard-Jensen J. Growing literature, stagnant science? Systematic review, meta-regression and cumulative analysis of audit and feedback interventions in health care. J Gen Intern Med 2014; 29: 1534-1541.
Jamtvedt G, Young JM, Kristoffersen DT, O'Brien MA, Oxman AD. Audit and feedback: effects on professional practice and health care outcomes. Cochrane Database Syst Rev 2006: Cd000259.
Shanbhag D, Graham ID, Harlos K, Haynes RB, Gabizon I, Connolly SJ, Van Spall HGC. Effectiveness of implementation interventions in improving physician adherence to guideline recommendations in heart failure: a systematic review. BMJ Open 2018; 8: e017765.
Calvert MJ, Shankar A, McManus RJ, Ryan R, Freemantle N. Evaluation of the management of heart failure in primary care. Fam Pract 2009; 26: 145-153.
Tebbe U, Tschope C, Wirtz JH, Lokies J, Turgonyi E, Bramlage P, Strunz AM, Lins K, Bohm M. Registry in Germany focusing on level-specific and evidence-based decision finding in the treatment of heart failure: REFLECT-HF. Clinical rese cardio: official j German Cardiac Soc 2014; 103: 665-673.
Smeets M, Aertgeerts B, Mullens W, Penders J, Vercammen J, Janssens S, Vaes B. Optimising standards of care of heart failure in general practice the OSCAR-HF pilot study protocol. Acta Cardiol 2019; 74: 371-379.
van Royen P, Boulanger S, Chevalier P, Dekeulenaer G, Goossens M, Koeck P, Vanhalewyn M, van den Heuvel P. Aanbeveling voor goede medische praktijkvoering: Chronisch hartfalen. Huisarts Nu 2011; 40: 158-186.
Belgisch Centrum voor Farmacotherapeutische Informatie (BCFI). www.bcfi.be. (13 August 2020).
Middel B, Bouma J, de Jongste M, van Sonderen E, Niemeijer MG, van den Heuvel W. Psychometric properties of the Minnesota Living with Heart Failure Questionnaire (MLHF-Q). Clin Rehabil 2001; 15: 489-500.
Legrand D, Vaes B, Mathei C, Swine C, Degryse JM. The prevalence of sarcopenia in very old individuals according to the European consensus definition: insights from the BELFRAIL study. Age Ageing 2013; 42: 727-734.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-423.
Vaduganathan M, Michel A, Hall K, Mulligan C, Nodari S, Shah SJ, Senni M, Triggiani M, Butler J, Gheorghiade M. Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review. Eur J Heart Fail 2016; 18: 54-65.
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH. Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review. Eur J Heart Fail 2016; 18: 242-252.
Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, Allison M, Hemingway H, Cleland JG, McMurray JJV, Rahimi K. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet 2018; 391: 572-580.
Hartung DM, Hunt J, Siemienczuk J, Miller H, Touchette DR. Clinical implications of an accurate problem list on heart failure treatment. J Gen Intern Med 2005; 20: 143-147.
McCormick N, Lacaille D, Bhole V, Avina-Zubieta JA. Validity of heart failure diagnoses in administrative databases: a systematic review and meta-analysis. PLoS ONE 2014; 9: e104519.
Verdu-Rotellar JM, Frigola-Capell E, Alvarez-Perez R, da Silva D, Enjuanes C, Domingo M, Mena A, Munoz MA. Validation of heart failure diagnosis registered in primary care records in two primary care centres in Barcelona (Spain) and factors related. A cross-sectional study. Eur J Gen Pract 2017; 23: 107-113.
Pieske B, Tschope C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G. How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 2019; 40: 3297-3317.
Vaillant-Roussel H, Laporte C, Pereira B, De RM, Eschalier B, Vorilhon C, Eschalier R, Clement G, Pouchain D, Chenot JF, Dubray C, Vorilhon P. Impact of patient education on chronic heart failure in primary care (ETIC): a cluster randomised trial. BMC Fam Pract 2016; 17: 80.
Nijst P, Martens P, Mullens W. Heart failure with myocardial recovery-the patient whose heart failure has improved: what next? Prog Cardiovasc Dis 2017; 60: 226-236.
Monahan M, Barton P, Taylor CJ, Roalfe AK, Hobbs FDR, Cowie M, Davis R, Deeks J, Mant J, McCahon D, McDonagh T, Sutton G, Tait L. MICE or NICE? An economic evaluation of clinical decision rules in the diagnosis of heart failure in primary care. Int J Cardiol 2017; 241: 255-261.
Toggweiler S, Borst O, Enseleit F, Hermann M, Ruschitzka F, Luscher TF, Noll G. NT-proBNP provides incremental prognostic information in cardiac outpatients with and without echocardiographic findings. Clin Cardiol 2011; 34: 183-188.
Smeets M, De Witte P, Peters S, Aertgeerts B, Janssens S, Vaes B. Think-aloud study about the diagnosis of chronic heart failure in Belgian general practice. BMJ Open 2019; 9: e025922.
Hirt MN, Muttardi A, Helms TM, van den Bussche H, Eschenhagen T. General practitioners' adherence to chronic heart failure guidelines regarding medication: the GP-HF study. Clinical rese cardio: official j German Cardiac Soc 2016; 105: 441-450.
Atherton JJ, Hickey A. Expert comment: is medication titration in heart failure too complex? Card Fail Rev 2017; 3: 25-32.
Ansari M, Alexander M, Tutar A, Bello D, Massie BM. Cardiology participation improves outcomes in patients with new-onset heart failure in the outpatient setting. J Am Coll Cardiol 2003; 41: 62-68.
van der Wel MC, Jansen RW, Bakx JC, Bor HH, Olderikkert MG, van Weel C. Non-cardiovascular co-morbidity in elderly patients with heart failure outnumbers cardiovascular co-morbidity. Eur J Heart Fail 2007; 9: 709-715.
Moser DK, Heo S, Lee KS, Hammash M, Riegel B, Lennie TA, Arslanian-Engoren C, Mudd-Martin G, Albert N, Watkins J. ‘It could be worse … lot's worse!’ Why health-related quality of life is better in older compared with younger individuals with heart failure. Age Ageing 2013; 42: 626-632.

Auteurs

Miek Smeets (M)

Department of Public Health and Primary Care, KU Leuven (KUL), Leuven, Belgium.

Bert Vaes (B)

Department of Public Health and Primary Care, KU Leuven (KUL), Leuven, Belgium.
Institute of Health and Society, Université Catholique de Louvain (UCL), Brussels, Belgium.

Bert Aertgeerts (B)

Department of Public Health and Primary Care, KU Leuven (KUL), Leuven, Belgium.

Willem Raat (W)

Department of Public Health and Primary Care, KU Leuven (KUL), Leuven, Belgium.

Joris Penders (J)

Department of Clinical Biology, Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium.
Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.

Jan Vercammen (J)

Department of Cardiology, Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium.

Walter Droogne (W)

Department of Cardiovascular Diseases, Universitair Ziekenhuis Gasthuisberg, KU Leuven (KUL), Leuven, Belgium.

Wilfried Mullens (W)

Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
Department of Cardiology, Ziekenhuis Oost-Limburg (ZOL), Genk, Belgium.

Stefan Janssens (S)

Department of Cardiovascular Diseases, Universitair Ziekenhuis Gasthuisberg, KU Leuven (KUL), Leuven, Belgium.

Classifications MeSH