Independent reaction times method in Geant4-DNA: Implementation and performance.
Geant4-DNA
LET
Monte Carlo
independent reaction times
radiolysis
track-structure
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
10
07
2020
revised:
07
09
2020
accepted:
13
09
2020
pubmed:
25
9
2020
medline:
15
5
2021
entrez:
24
9
2020
Statut:
ppublish
Résumé
The simulation of individual particle tracks and the chemical stage following water radiolysis in biological tissue is an effective means of improving our knowledge of the physico-chemical contribution to the biological effect of ionizing radiation. However, the step-by-step simulation of the reaction kinetics of radiolytic species is the most time-consuming task in Monte Carlo track-structure simulations, with long simulation times that are an impediment to research. In this work, we present the implementation of the independent reaction times (IRT) method in Geant4-DNA Monte Carlo toolkit to improve the computational efficiency of calculating G-values, defined as the number of chemical species created or lost per 100 eV of deposited energy. The computational efficiency of IRT, as implemented, is compared to that from available Geant4-DNA step-by-step simulations for electrons, protons and alpha particles covering a wide range of linear energy transfer (LET). The accuracy of both methods is verified using published measured data from fast electron irradiations for The IRT improved the computational efficiency by three orders of magnitude relative to the step-by-step method while differences in G-values by 3.9% at 1 μs were found. At 7 ps, The comprehensive validation of the Geant4-DNA capabilities to accurately simulate the chemistry following water radiolysis is an ongoing work. The implementation presented in this work is a necessary step to facilitate performing such a task.
Identifiants
pubmed: 32970844
doi: 10.1002/mp.14490
pmc: PMC7891885
mid: NIHMS1632026
doi:
Substances chimiques
Water
059QF0KO0R
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5919-5930Subventions
Organisme : NCI NIH HHS
ID : R01 CA187003
Pays : United States
Organisme : UCSF Medical School Bridge
ID : NIH R01 CA187003
Informations de copyright
© 2020 American Association of Physicists in Medicine.
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