Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus.
Allergy
IgE
atopy
eye rubbing
keratoconus
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
entrez:
25
9
2020
pubmed:
26
9
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Keratoconus (KC) is an ectatic disease of the cornea characterized by localized thinning and protrusion causing irregular astigmatism, which can lead to significant visual impairment. KC has often been associated with allergy and/or atopy, which are immune-mediated inflammatory reactions primarily driven by IgE. A higher proportion of KC patients were reported to have history or suffer from systemic and/or ocular allergy with elevated allergen-specific IgE and/or total serum IgE. Eye rubbing, one of the risk factors for worsening of the disease and developing related complications in KC, is associated with IgE driven conditions. The current review enumerates and contextualizes the evidence related to IgE in mediating KC pathogenesis, including aberrant extra-cellular matrix remodeling. This review also discusses clinical strategies directed at modulating IgE-mediated responses in the management of KC, and the emerging academic and plausible clinical relevance of assessing serum and tear IgE (allergen-specific and total) status in improving the understanding of disease pathobiology, treatment planning, and prognosis.
Identifiants
pubmed: 32971611
pii: IndianJOphthalmol_2020_68_10_2067_295661
doi: 10.4103/ijo.IJO_1191_19
pmc: PMC7727983
doi:
Substances chimiques
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2067-2074Déclaration de conflit d'intérêts
None
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