The Prognosis and Recurrence Pattern of Right- and Left-Sided Colon Cancer in Stage II, Stage III, and Liver Metastasis After Curative Resection.
Colorectal liver metastasis
Left-sided colon cancer
Right-sided colon cancer
Journal
Annals of coloproctology
ISSN: 2287-9714
Titre abrégé: Ann Coloproctol
Pays: Korea (South)
ID NLM: 101605121
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
12
06
2020
accepted:
14
09
2020
pubmed:
26
9
2020
medline:
26
9
2020
entrez:
25
9
2020
Statut:
ppublish
Résumé
Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested the impact was varied by tumor stage. This study analyzed the prognostic impact of the sidedness of colon cancer in stages II, III, and liver metastasis after curative resection using propensity-matched analysis. Right-sided colon cancer was defined as a tumor located from cecum to splenic flexure, while any more distal colon cancer was defined as left-sided colon cancer. Patients who underwent curative resection at Nara Medical University hospital between 2000 and 2016 were analyzed. There were 110 patients with stage II, 100 patients with stage III, and 106 patients with liver metastasis. After propensity matching, 28 pairs with stage II and 32 pairs with stage III were identified. In the patients with stage II, overall survival (OS) and recurrence-free survival (RFS) were not significantly different for right- and left-sided colon cancers. In the patients with stage III, OS and RFS were significantly worse in right-sided colon cancer. In those with liver metastasis, OS of right-sided colon cancer was significantly worse than left-sided disease, while RFS was similar. Regarding metachronous liver metastasis, the difference was observed only in the patients whose primary colon cancer was stage III. In each stage, significantly higher rate of peritoneal recurrence was found in those with right-sided colon cancer. Sidedness of colon cancer had a significant and varied prognostic impact in patients with stage II, III, and liver metastasis after curative resection.
Identifiants
pubmed: 32972100
pii: ac.2020.09.14
doi: 10.3393/ac.2020.09.14
pmc: PMC8566149
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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