Predictive capacity of IL-8 expression in head and neck squamous carcinoma patients treated with radiotherapy or chemoradiotherapy.
Capacidad predictiva de la expresión de IL-8 en pacientes con carcinomas escamosos de cabeza y cuello tratados con radioterapia o quimio-radioterapia.
CXCL8
Carcinoma escamoso de cabeza y cuello
Chemo-radiotherapy
Control local
Head and neck squamous cell carcinoma
IL-8
Interleucina-8
Interleukin-8
Local control
Local recurrence
Quimio-radioterapia
Radioterapia
Radiotherapy
Recidiva local
Journal
Acta otorrinolaringologica espanola
ISSN: 2173-5735
Titre abrégé: Acta Otorrinolaringol Esp (Engl Ed)
Pays: Spain
ID NLM: 101770938
Informations de publication
Date de publication:
21 Sep 2020
21 Sep 2020
Historique:
received:
14
03
2020
revised:
01
05
2020
accepted:
08
05
2020
entrez:
25
9
2020
pubmed:
26
9
2020
medline:
26
9
2020
Statut:
aheadofprint
Résumé
To analyse the relationship between the transcriptional expression of interleukin-8 (IL-8) and response to treatment with radiotherapy or chemo-radiotherapy in patients with squamous cell carcinoma of the head and neck (SCCHN). Retrospective study from tumour biopsies obtained before a treatment with radiotherapy or chemo-radiotherapy in 87 patients with SCCHN. We had a sample of healthy mucosa in 35 cases. We determined the transcriptional expression of IL-8 with RT-PCR. The transcriptional expression of IL-8 was categorized according to the local control of the disease with a recursive partitioning analysis. The transcriptional expression of IL-8 in tumour tissue was about 50 times higher than that in the samples of healthy mucosa. Patients with a high transcriptional expression of IL-8 (n=56) had a 5-year local recurrence-free survival of 65.6%, and for patients with low expression (n=31) it was 90.2% (P=.017). According to the results of a multivariate analysis, patients with high expression of IL-8 had a 4.1 higher risk of local recurrence of the tumour. SCCHN have a significant increase in transcriptional expression of IL-8 in relation to non-tumour tissue. Tumours with high IL-8 expression have an increased risk of local recurrence after treatment with radiotherapy or chemo-radiotherapy.
Identifiants
pubmed: 32972719
pii: S0001-6519(20)30146-1
doi: 10.1016/j.otorri.2020.05.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.