Comparison of semiquantitative and differential time to positivity methods for the diagnosis of central line-associated bloodstream infections in an intensive care unit.
central line-associated bloodstream infections
differential time to positivity
intensive care
semiquantitative method
Journal
Access microbiology
ISSN: 2516-8290
Titre abrégé: Access Microbiol
Pays: England
ID NLM: 101746927
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
04
2019
accepted:
08
05
2019
entrez:
25
9
2020
pubmed:
5
6
2019
medline:
5
6
2019
Statut:
epublish
Résumé
Central line-associated bloodstream infections (CLABSIs) adversely affect patients' hospitalization. We compared semiquantitative roll plate (SQRP) and differential time to positivity (DTP) culture methods in diagnosing CLABSIs. A retrospective study was conducted in an intensive care unit (ICU) from January 2013 to August 2014. All ICU patients with suspected CLABSIs were included. Blood cultures were taken, while central venous catheter (CVC) tips were cultured using the roll-tip method. DTP was considered positive if CVC lumen blood cultures became positive at least 2 h prior to concurrently drawn peripheral blood cultures with an identical micro-organism. SQRP method was considered positive when ≥15 c.f.u. of a micro-organism identical to that of blood cultures grew. Measures of diagnostic accuracy were calculated. SQRP displayed high sensitivity (94.7 %), while DTP showed high specificity (82.5 %). SQRP combined with DTP displayed 100 % sensitivity and negative predictive value. SQRP and DTP methods should be evaluated in combination.
Identifiants
pubmed: 32974522
doi: 10.1099/acmi.0.000029
pii: 000029
pmc: PMC7470290
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e000029Informations de copyright
© 2019 The Authors.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
Références
Crit Care Med. 2009 Jul;37(7):2283-9
pubmed: 19487944
Crit Care Med. 2001 Jul;29(7):1399-403
pubmed: 11445695
Intensive Care Med. 2018 Jun;44(6):742-759
pubmed: 29754308
Antimicrob Agents Chemother. 2018 Aug 27;62(9):
pubmed: 29987150
Crit Care Med. 2010 Apr;38(4):1030-5
pubmed: 20154601
Clin Infect Dis. 2007 Mar 15;44(6):820-6
pubmed: 17304454
Lancet. 1999 Sep 25;354(9184):1071-7
pubmed: 10509498
JAMA Intern Med. 2016 Dec 1;176(12):1843-1854
pubmed: 27775764
Crit Care Med. 2005 Apr;33(4):787-91
pubmed: 15818106
Intensive Care Med. 2013 Jan;39(1):109-16
pubmed: 23011530
Clin Infect Dis. 2009 Jul 1;49(1):1-45
pubmed: 19489710
Intensive Care Med. 2004 Jun;30(6):1005-7
pubmed: 14991086
EJIFCC. 2009 Jan 20;19(4):203-11
pubmed: 27683318
Clin Infect Dis. 2005 Apr 15;40(8):1096-100
pubmed: 15791507
Ann Intern Med. 2005 Mar 15;142(6):451-66
pubmed: 15767623
N Engl J Med. 1977 Jun 9;296(23):1305-9
pubmed: 323710
Crit Care. 2010;14(2):212
pubmed: 20236456