Temporary/Permanent Dual Cross-Link Gels Formed of a Bioactive Lactose-Modified Chitosan.
adaptable mechanics
bioactive biopolymer
dual cross-link hydrogel
mechanotransduction
tissue engineering
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
09
07
2020
revised:
09
09
2020
pubmed:
26
9
2020
medline:
14
10
2021
entrez:
25
9
2020
Statut:
ppublish
Résumé
Mounting evidences have recognized that dual cross-link and double-network gels can promisingly recapitulate the complex living tissue architecture and overcome mechanical limitations of conventional scaffolds used hitherto in regenerative medicine. Here, dual cross-link gels formed of a bioactive lactose-modified chitosan reticulated via both temporary (boric acid-based) and permanent (genipin-based) cross-linkers are reported. While boric acid rapidly binds to lactitol flanking diols increasing the overall viscosity, a slow temperature-driven genipin binding process takes place allowing for network strengthening. Combination of frequency and stress sweep experiments in the linear stress-strain region shows that ultimate gel strength, toughness, and viscoelasticity depend on polymer-to-genipin molar ratio. Notably, herewith it is demonstrated that linear stretching correlates with strain energy dissipation through boric acid binding/unbinding dynamics. Strain-hardening effect in the nonlinear regime, along with good biocompatibility in vitro, points at an interesting role of present system as biological extracellular matrix substitute.
Identifiants
pubmed: 32975019
doi: 10.1002/mabi.202000236
doi:
Substances chimiques
Biocompatible Materials
0
Boric Acids
0
Gels
0
Iridoids
0
Chitosan
9012-76-4
genipin
A3V2NE52YG
Lactose
J2B2A4N98G
boric acid
R57ZHV85D4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000236Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
D. E. Discher, P. Janmey, Y.-L. Wang, Science 2005, 310, 1139.
J. Swift, I. L. Ivanovska, A. Buxboim, T. Harada, P. C. D. P. Dingal, J. Pinter, J. D. Pajerowski, K. R. Spinler, J.-W. Shin, M. Tewari, F. Rehfeldt, D. W. Speicher, D. E. Discher, Science 2013, 341, 1240104.
D. E. Discher, D. J. Mooney, P. W. Zandstra, Science 2009, 324, 1673.
T. Mammoto, D. E. Ingber, Development 2010, 137, 1407.
T. Panciera, L. Azzolin, M. Cordenonsi, S. Piccolo, Nat. Rev. Mol. Cell Biol. 2017, 18, 758.
G. Brusatin, T. Panciera, A. Gandin, A. Citron, S. Piccolo, Nat. Mater. 2018, 17, 1063.
J. A. Burdick, W. L. Murphy, Nat. Commun. 2012, 3, 1269.
W. L. A. Brooks, B. S. Sumerlin, Chem. Rev. 2016, 116, 1375.
M. E. Smithmyer, C. C. Deng, S. E. Cassel, P. J. LeValley, B. S. Sumerlin, A. M. Kloxin, ACS Macro Lett. 2018, 7, 1105.
Y. Chen, D. Diaz-Dussan, D. Wu, W. Wang, Y.-Y. Peng, A. B. Asha, D. G. Hall, K. Ishihara, R. Narain, ACS Macro Lett. 2018, 7, 904.
S. Tang, H. Ma, H.-C. Tu, H.-R. Wang, P.-C. Lin, K. S. Anseth, Adv. Sci. 2018, 5, 1800638.
F. Furlani, P. Sacco, M. Cok, G. de Marzo, E. Marsich, S. Paoletti, I. Donati, ACS Biomater. Sci. Eng. 2019, 5, 5539.
J.-Y. Sun, X. Zhao, W. R. K. Illeperuma, O. Chaudhuri, K. H. Oh, D. J. Mooney, J. J. Vlassak, Z. Suo, Nature 2012, 489, 133.
K. Mayumi, A. Marcellan, G. Ducouret, C. Creton, T. Narita, ACS Macro Lett. 2013, 2, 1065.
T. Narita, K. Mayumi, G. Ducouret, P. Hébraud, Macromolecules 2013, 46, 4174.
T. L. Sun, T. Kurokawa, S. Kuroda, A. Bin Ihsan, T. Akasaki, K. Sato, M. A. Haque, T. Nakajima, J. P. Gong, Nat. Mater. 2013, 12, 932.
I. Donati, S. Stredanska, G. Silvestrini, A. Vetere, P. Marcon, E. Marsich, P. Mozetic, A. Gamini, S. Paoletti, F. Vittur, Biomaterials 2005, 26, 987.
A. Travan, E. Marsich, I. Donati, M.-P. Foulc, N. Moritz, H. T. Aro, S. Paoletti, Biomacromolecules 2012, 13, 1564.
M. Medelin, D. Porrelli, E. R. Aurand, D. Scaini, A. Travan, M. A. Borgogna, M. Cok, I. Donati, E. Marsich, C. Scopa, R. Scardigli, S. Paoletti, L. Ballerini, Acta Biomater. 2018, 73, 285.
P. Sacco, F. Furlani, S. Paoletti, I. Donati, Biomacromolecules 2019, 20, 3070.
A. M. Heimbuck, T. R. Priddy-Arrington, M. L. Padgett, C. B. Llamas, H. H. Barnett, B. A. Bunnell, M. E. Caldorera-Moore, ACS Appl. Bio Mater. 2019, 2, 2879.
S. Dimida, C. Demitri, V. M. De Benedictis, F. Scalera, F. Gervaso, A. Sannino, J. Appl. Polym. Sci. 2015, 132, 42256.
P. Sacco, F. Furlani, M. Cok, A. Travan, M. Borgogna, E. Marsich, S. Paoletti, I. Donati, Biomacromolecules 2017, 18, 4206.
F. Furlani, P. Sacco, F. Scognamiglio, F. Asaro, A. Travan, M. Borgogna, E. Marsich, M. Cok, S. Paoletti, I. Donati, Carbohydr. Polym. 2019, 208, 451.
A. Maleki, A.-L. Kjøniksen, B. Nyström, Carbohydr. Res. 2007, 342, 2776.
E. E. Holly, S. K. Venkataraman, F. Chambon, H. H. Winter, J. Non-Newtonian Fluid Mech. 1988, 27, 17.
F.-L. Mi, S.-S. Shyu, C.-K. Peng, J. Polym. Sci., Part A: Polym. Chem. 2005, 43, 1985.
C. Branco da Cunha, D. D. Klumpers, W. A. Li, S. T. Koshy, J. C. Weaver, O. Chaudhuri, P. L. Granja, D. J. Mooney, Biomaterials 2014, 35, 8927.
T. Indei, J. Takimoto, J. Chem. Phys. 2010, 133, 194902.
M. Cok, P. Sacco, D. Porrelli, A. Travan, M. Borgogna, E. Marsich, S. Paoletti, I. Donati, Int. J. Biol. Macromol. 2018, 106, 656.
K. A. Erk, K. J. Henderson, K. R. Shull, Biomacromolecules 2010, 11, 1358.
ISO 10993-5: Biological Evaluation of Medical Devices-Part 5: Tests for In Vitro Cytotoxicity, 2nd ed., 2009.
C. Storm, J. J. Pastore, F. C. MacKintosh, T. C. Lubensky, P. A. Janmey, Nature 2005, 435, 191.
F. Furlani, P. Sacco, E. Marsich, I. Donati, S. Paoletti, Carbohydr. Polym. 2017, 174, 360.
P. Sacco, F. Brun, I. Donati, D. Porrelli, S. Paoletti, G. Turco, ACS Appl. Mater. Interfaces 2018, 10, 10761.