Dentifrices or gels containing MMP inhibitors prevent dentine loss: in situ studies.
Dentine
Erosion
Gels
Inhibitors
Matrix metalloproteinases
Toothpastes
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
31
01
2020
accepted:
14
08
2020
pubmed:
26
9
2020
medline:
19
3
2021
entrez:
25
9
2020
Statut:
ppublish
Résumé
Evaluate the effect of dentifrices or gels containing MMP inhibitors on dentine loss in situ. Acrylic palatal appliances containing bovine dentine blocks were divided into two rows, corresponding to the groups erosion (ERO) and erosion associated with abrasion (ERO+ABR). For ERO, the appliances were immersed in a cola drink for 5 min, 4 times/day, while for ERO+ABR, the blocks were brushed for 15 sec with a dentifrice slurry after the second and third erosive challenges. Ten volunteers took part in study 1 (S1), where the dentifrices evaluated contained 1100 ppm fluoride as NaF, 0.61% green tea extract, or 0.012% chlorhexidine digluconate. Thirteen volunteers participated in study 2 (S2), in which the treatment was performed only once (1 min) with gels containing 400 μM EGCG (EGCG400), 0.012% chlorhexidine, 1 mM FeSO Regarding S1, ERO+ABR induced significantly higher dentine loss compared with ERO and all dentifrices tested led to significantly lower dentine loss when compared with placebo. For S2, regardless of the conditions or times of evaluation, gels containing EGCG, CHX, or FeSO Both dentifrices and gels containing MMP inhibitors significantly reduced dentine loss. Dentifrices and gels containing MMP inhibitors are able to increase the protection against dentine wear, although gels have a better effect when compared with fluoride gel, lasting up to 10 days after a single application.
Identifiants
pubmed: 32975705
doi: 10.1007/s00784-020-03530-y
pii: 10.1007/s00784-020-03530-y
doi:
Substances chimiques
Dentifrices
0
Gels
0
Matrix Metalloproteinase Inhibitors
0
Sodium Fluoride
8ZYQ1474W7
Fluorides
Q80VPU408O
Types de publication
Journal Article
Langues
eng
Pagination
2183-2190Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 07/08389-3, 07/04209-0, 08/09857-3 and 07/54618-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 557863/2008-2 and 300615/2007-8
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