Tick-Borne Flaviviruses Depress AKT Activity during Acute Infection by Modulating AKT1/2.
AKT
Langat virus
apoptosis
tick-borne flavivirus
viral persistence
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
23 09 2020
23 09 2020
Historique:
received:
19
06
2020
revised:
17
09
2020
accepted:
18
09
2020
entrez:
26
9
2020
pubmed:
27
9
2020
medline:
10
2
2021
Statut:
epublish
Résumé
Tick-borne flaviviruses (TBFVs) are reemerging public health threats. To develop therapeutics against these pathogens, increased understanding of their interactions with the mammalian host is required. The PI3K-AKT pathway has been implicated in TBFV persistence, but its role during acute virus infection remains poorly understood. Previously, we showed that Langat virus (LGTV)-infected HEK 293T cells undergo a lytic crisis with a few surviving cells that become persistently infected. We also observed that
Identifiants
pubmed: 32977414
pii: v12101059
doi: 10.3390/v12101059
pmc: PMC7598186
pii:
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Références
Cancer Res. 2001 Aug 1;61(15):5911-8
pubmed: 11479233
Cell Signal. 2011 Dec;23(12):1952-60
pubmed: 21777670
J Virol. 2001 Jul;75(13):6022-32
pubmed: 11390604
Euro Surveill. 2019 Nov;24(47):
pubmed: 31771701
Antioxid Redox Signal. 2011 Jul 1;15(1):1-17
pubmed: 21303257
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Eur J Neurol. 2017 Oct;24(10):1214-e61
pubmed: 28762591
Viruses. 2018 Jun 16;10(6):
pubmed: 29914165
Am J Trop Med Hyg. 2001 Nov;65(5):671-6
pubmed: 11716135
J Virol. 2005 Oct;79(20):12828-39
pubmed: 16188985
mBio. 2016 May 24;7(3):
pubmed: 27222466
Rev Med Virol. 2015 Jul;25(4):205-23
pubmed: 25828437
J Virol Methods. 2001 Mar;92(1):37-44
pubmed: 11164916
Biochem J. 2010 Sep 1;430(2):199-205
pubmed: 20704571
Adv Virus Res. 2003;59:277-314
pubmed: 14696332
J Virol. 2017 Jan 18;91(3):
pubmed: 27881649
J Gen Virol. 2009 Sep;90(Pt 9):2081-5
pubmed: 19474250
Euro Surveill. 2018 Nov;23(45):
pubmed: 30424829
Virology. 2018 Mar;516:147-157
pubmed: 29358114
Cancer Res. 2011 Jul 1;71(13):4720-31
pubmed: 21555366
Cent Eur J Public Health. 2009 Sep;17(3):139-45
pubmed: 20020603
PLoS One. 2012;7(10):e47912
pubmed: 23112871
Antiviral Res. 2013 May;98(2):192-208
pubmed: 23523765
Genes Dev. 2001 Sep 1;15(17):2203-8
pubmed: 11544177
Scand J Infect Dis. 1996;28(3):217-24
pubmed: 8863349
Viruses. 2017 Apr 30;9(5):
pubmed: 28468299
Curr Opin Virol. 2012 Oct;2(5):614-21
pubmed: 23057872
Viruses. 2013 Dec 16;5(12):3192-212
pubmed: 24351799
Arch Virol. 2009;154(5):811-20
pubmed: 19363586
J Virol. 2002 Apr;76(8):3731-8
pubmed: 11907212
J Virol. 2008 May;82(10):4731-41
pubmed: 18337583
Cell Commun Signal. 2019 Nov 21;17(1):154
pubmed: 31752925
Viruses. 2011 Sep;3(9):1739-56
pubmed: 21994804
J Virol. 2013 Jan;87(2):872-81
pubmed: 23115297
Development. 2005 Jul;132(13):2943-54
pubmed: 15930105
Nat Immunol. 2002 Nov;3(11):1090-6
pubmed: 12389041
Neurochem Res. 2009 May;34(5):991-1001
pubmed: 18949556
Genes Dev. 2006 Aug 15;20(16):2238-49
pubmed: 16882970
PLoS Pathog. 2008 Aug 29;4(8):e1000141
pubmed: 18769720
Cell. 2017 May 4;169(4):610-620.e14
pubmed: 28457610
J Virol. 2003 Jan;77(1):25-36
pubmed: 12477807
Cancer Res. 2004 Oct 1;64(19):7002-10
pubmed: 15466193
Vaccine. 2003 Apr 1;21 Suppl 1:S11-8
pubmed: 12628810
Antiviral Res. 2015 Jun;118:148-58
pubmed: 25842996
Clin Infect Dis. 2002 Sep 15;35(6):650-8
pubmed: 12203160
Oncogene. 2003 Dec 8;22(56):8983-98
pubmed: 14663477
Science. 2004 May 28;304(5675):1325-8
pubmed: 15166380
Cell Stem Cell. 2016 Nov 3;19(5):663-671
pubmed: 27524440
mBio. 2015 May 12;6(3):e00553-15
pubmed: 25968648
Euro Surveill. 2008 Jun 26;13(26):
pubmed: 18761916
Cell Death Differ. 2013 Oct;20(10):1341-9
pubmed: 23787999
Virus Res. 2013 Dec 26;178(2):471-7
pubmed: 24177270
Virology. 2008 Apr 25;374(1):170-85
pubmed: 18234265
Virology. 2018 Jan 15;514:98-105
pubmed: 29156399
Nature. 1956 Sep 15;178(4533):581-2
pubmed: 13369466
Curr Opin Virol. 2017 Apr;23:95-101
pubmed: 28486135
Euro Surveill. 2016 Aug 18;21(33):
pubmed: 27562931
J Virol. 2005 Jul;79(13):8388-99
pubmed: 15956583
Cancer Cell. 2008 Dec 9;14(6):458-70
pubmed: 19061837
Sci Signal. 2009 Oct 13;2(92):ra62
pubmed: 19825827
mBio. 2015 Jun 04;6(3):e00614
pubmed: 26045539
Cell Cycle. 2009 Aug 15;8(16):2502-8
pubmed: 19597332