Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery.
TMBIM
cell death
cell survival
mitochondria
mitochondrial metabolism
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 09 2020
23 09 2020
Historique:
received:
27
08
2020
revised:
18
09
2020
accepted:
18
09
2020
entrez:
26
9
2020
pubmed:
27
9
2020
medline:
14
5
2021
Statut:
epublish
Résumé
The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and has been implicated in cell death susceptibility. The only member with a mitochondrial localization is TMBIM5 (also known as GHITM or MICS1), which affects cristae organization and associates with the Parkinson's disease-associated protein CHCHD2 in the inner mitochondrial membrane. We here used CRISPR-Cas9-mediated knockout HAP1 cells to shed further light on the function of TMBIM5 in physiology and cell death susceptibility. We found that compared to wild type,
Identifiants
pubmed: 32977469
pii: cells9102147
doi: 10.3390/cells9102147
pmc: PMC7598220
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
Membrane Proteins
0
Mitochondrial Proteins
0
bcl-2-Associated X Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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