c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.

Animals Cytokines / metabolism Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental / metabolism JNK Mitogen-Activated Protein Kinases / metabolism Mice, Inbred C57BL Multiple Sclerosis / metabolism Myelin-Oligodendrocyte Glycoprotein / metabolism T-Lymphocytes / immunology
MAPK SP600125 immunotherapy mitogen-activated protein kinases multiple sclerosis neuroinflammation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
23 09 2020
Historique:
received: 03 09 2020
accepted: 16 09 2020
entrez: 26 9 2020
pubmed: 27 9 2020
medline: 14 5 2021
Statut: epublish

Résumé

c-Jun N-terminal kinase (JNK) is upregulated during multiple sclerosis relapses and at the peak of experimental autoimmune encephalomyelitis (EAE). We aim to investigate the effects of pharmacological pan-JNK inhibition on the course of myelin oligodendrocyte glycoprotein (MOG

Identifiants

DOI: 10.3390/cells9102154 PMID: 32977663 PMC: PMC7598244
pubmed: 32977663
pii: cells9102154
doi: 10.3390/cells9102154
pmc: PMC7598244
pii:
doi:

Substances chimiques

Cytokines 0
Myelin-Oligodendrocyte Glycoprotein 0
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Maud Bagnoud (M)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010 Bern, Switzerland.

Myriam Briner (M)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.

Jana Remlinger (J)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010 Bern, Switzerland.

Ivo Meli (I)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.

Sara Schuetz (S)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.

Maximilian Pistor (M)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
ORCID: 0000-0002-0703-9974

Anke Salmen (A)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
ORCID: 0000-0002-4751-299X

Andrew Chan (A)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.

Robert Hoepner (R)

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Glycoprotéine MOG › c-Jun N-Terminal Kinase as a Therapeutic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › c-Jun N-Terminal Kinase as a Therapeutic...