SCD1 promotes lipid mobilization in subcutaneous white adipose tissue.
adipocytes
lipolysis
lipophagy
oleic acid
stearoyl-CoA desaturase-1
thermogenesis
triacylglycerol
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
27
9
2020
medline:
26
10
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol [TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1's products, oleic acid (OA). OA upregulated adipose TAG lipase and hormone-sensitive lipase expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation were increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in upregulating lipid mobilization through its desaturation product, OA.
Identifiants
pubmed: 32978274
pii: S0022-2275(20)60021-9
doi: 10.1194/jlr.RA120000869
pmc: PMC7707166
pii:
doi:
Substances chimiques
Stearoyl-CoA Desaturase
EC 1.14.19.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1589-1604Informations de copyright
Copyright © 2020 Zou et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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