Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 09 2020
25 09 2020
Historique:
received:
12
12
2019
accepted:
24
08
2020
entrez:
26
9
2020
pubmed:
27
9
2020
medline:
18
12
2020
Statut:
epublish
Résumé
The gravity is necessary for living organisms to operate various biological events including hippocampus-related functions of learning and memory. Until now, it remains inconclusive how altered gravity is associated with hippocampal functions. It is mainly due to the difficulties in generating an animal model experiencing altered gravity. Here, we demonstrate the effects of hypergravity on hippocampus-related functions using an animal behavior and electrophysiology with our hypergravity animal model. The hypergravity (4G, 4 weeks) group showed impaired synaptic efficacy and long-term potentiation in CA1 neurons of the hippocampus along with the poor performance of a novel object recognition task. Our studies suggest that altered gravity affects hippocampus-related cognitive functions, presumably through structural and functional adaptation to various conditions of gravity shift.
Identifiants
pubmed: 32978417
doi: 10.1038/s41598-020-72639-7
pii: 10.1038/s41598-020-72639-7
pmc: PMC7519067
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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