Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients.
anemia
critical illness
pediatrics
platelet count
thrombocytosis
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
23
07
2020
revised:
01
09
2020
accepted:
11
09
2020
pubmed:
27
9
2020
medline:
15
5
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Extreme thrombocytosis (EXT, platelet count > 1000 × 10 Our objectives were to determine etiologies and sequelae of EXT in a hospitalized general pediatric patient population. We retrospectively analyzed EXT cases from a single-center pediatric cohort of ~80 000 patients over 8 years. Virtually all cases (99.8%) were secondary in nature, and most were multifactorial. Many cases of EXT occurred in children under 2 years old (47%) and/or during critical illness (55%). No thrombotic or bleeding events directly resulted from EXT, confirming a paucity of clinical complications associated with EXT in pediatric patients. There were indications that neonatal hematopoiesis and individual genetic variation influenced some cases, in addition to certain diagnoses (eg, sickle cell anemia) and clinical contexts (eg, asplenia). Our findings confirm that thrombotic events related to EXT are rare in pediatric patients, which can inform the use of empiric anti-platelet therapy.
Sections du résumé
BACKGROUND
Extreme thrombocytosis (EXT, platelet count > 1000 × 10
OBJECTIVES
Our objectives were to determine etiologies and sequelae of EXT in a hospitalized general pediatric patient population.
PATIENTS AND METHODS
We retrospectively analyzed EXT cases from a single-center pediatric cohort of ~80 000 patients over 8 years.
RESULTS
Virtually all cases (99.8%) were secondary in nature, and most were multifactorial. Many cases of EXT occurred in children under 2 years old (47%) and/or during critical illness (55%). No thrombotic or bleeding events directly resulted from EXT, confirming a paucity of clinical complications associated with EXT in pediatric patients. There were indications that neonatal hematopoiesis and individual genetic variation influenced some cases, in addition to certain diagnoses (eg, sickle cell anemia) and clinical contexts (eg, asplenia).
CONCLUSION
Our findings confirm that thrombotic events related to EXT are rare in pediatric patients, which can inform the use of empiric anti-platelet therapy.
Identifiants
pubmed: 32979018
doi: 10.1111/jth.15103
pmc: PMC7855272
mid: NIHMS1631587
pii: S1538-7836(22)03780-1
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3352-3358Subventions
Organisme : NICHD NIH HHS
ID : T32 HD043021
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : T32HD043021
Pays : International
Informations de copyright
© 2020 International Society on Thrombosis and Haemostasis.
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