Ambient ultrafine particle concentrations and incidence of childhood cancers.
Cancer
Children
Perinatal exposure
Ultrafine particle
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
19
05
2020
revised:
03
09
2020
accepted:
11
09
2020
pubmed:
27
9
2020
medline:
5
2
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Ambient air pollution has been associated with childhood cancer. However, little is known about the possible impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood cancer incidence. This study aimed to evaluate the association between prenatal and childhood exposure to UFPs and development of childhood cancer. We conducted a population-based cohort study of within-city spatiotemporal variations in ambient UFPs across the City of Toronto, Canada using 653,702 singleton live births occurring between April 1, 1998 and March 31, 2017. Incident cases of 13 subtypes of paediatric cancers among children up to age 14 were ascertained using a cancer registry. Associations between ambient air pollutant concentrations and childhood cancer incidence were estimated using random-effects Cox proportional hazards models. We investigated both single- and multi-pollutant models accounting for co-exposures to PM A total of 1,066 childhood cancers were identified. We found that first trimester exposure to UFPs (Hazard Ratio (HR) per 10,000/cm Ambient UFPs may represent a previously unrecognized risk factor in the aetiology of cancers in children. Our findings reinforce the importance of conducting further research on the effects of UFPs given their high prevalence of exposure in urban areas.
Sections du résumé
BACKGROUND
Ambient air pollution has been associated with childhood cancer. However, little is known about the possible impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood cancer incidence.
OBJECTIVE
This study aimed to evaluate the association between prenatal and childhood exposure to UFPs and development of childhood cancer.
METHODS
We conducted a population-based cohort study of within-city spatiotemporal variations in ambient UFPs across the City of Toronto, Canada using 653,702 singleton live births occurring between April 1, 1998 and March 31, 2017. Incident cases of 13 subtypes of paediatric cancers among children up to age 14 were ascertained using a cancer registry. Associations between ambient air pollutant concentrations and childhood cancer incidence were estimated using random-effects Cox proportional hazards models. We investigated both single- and multi-pollutant models accounting for co-exposures to PM
RESULTS
A total of 1,066 childhood cancers were identified. We found that first trimester exposure to UFPs (Hazard Ratio (HR) per 10,000/cm
CONCLUSION
Ambient UFPs may represent a previously unrecognized risk factor in the aetiology of cancers in children. Our findings reinforce the importance of conducting further research on the effects of UFPs given their high prevalence of exposure in urban areas.
Identifiants
pubmed: 32979813
pii: S0160-4120(20)32090-0
doi: 10.1016/j.envint.2020.106135
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106135Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.