Deciphering the Che2 chemosensory pathway and the roles of individual Che2 proteins from Pseudomonas aeruginosa.
Pseudomonas aeruginosa
adaptation
bacterial motility
chemosensing
response regulator
signal transduction
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
04
08
2020
revised:
15
09
2020
accepted:
16
09
2020
pubmed:
27
9
2020
medline:
31
8
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Pseudomonas aeruginosa is an opportunistic pathogen that senses and responds to its environment via four chemosensory systems. Oxygen activates the Che2 chemosensory system by binding to the PAS-heme domain of the Aer2 receptor. Ostensibly, the output of Che2 occurs via its response regulator CheY2, but controversy persists over CheY2's exact role. In this study, we show that CheY2 does not interact with the flagellar motor and that the Che2 system does not transfer phosphoryl groups to the chemotaxis (Che) system. We show that CheY2 instead provides feedback control of Aer2 adaptation. In the presence of O
Identifiants
pubmed: 32979856
doi: 10.1111/mmi.14612
pmc: PMC7897226
mid: NIHMS1634724
doi:
Substances chimiques
Bacterial Proteins
0
Carrier Proteins
0
Membrane Proteins
0
Methyl-Accepting Chemotaxis Proteins
0
Histidine Kinase
EC 2.7.13.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
222-237Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM108655
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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