Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms.
Adolescent
Biomarker
Schizophrenia
Sleep
Spindle
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
29
10
2019
revised:
24
05
2020
accepted:
25
08
2020
pubmed:
28
9
2020
medline:
22
6
2021
entrez:
27
9
2020
Statut:
ppublish
Résumé
Neuroimaging studies of childhood onset schizophrenia (COS), a rare yet severe form of schizophrenia with an onset before the age of 13 years, have shown continuity with adult onset schizophrenia. Previous research in adult patients has shown reduced sleep spindle activity, transient oscillations in the sleep electroencephalogram (EEG) generated through thalamocortical loops. The current study examines sleep spindle activity in patients with COS. Seventeen children and adolescents with COS (16 years ±6.6) underwent overnight sleep EEG recordings. Sleep spindle activity was compared between patients with COS and age and gender matched controls and correlated with clinical symptom severity. We found pronounced deficits in sleep spindle amplitude, duration, density and frequency in patients with COS (effect size = 0.61 to 1.96; dependent on metric and EEG derivation). Non-rapid eye movement (NREM) sleep EEG power and coherence in the sigma band (11-16 Hz) corresponding to spindle activity were also markedly diminished in patients with COS as compared to controls. Furthermore, the degree of deficit in power and coherence of spindles was strongly associated with clinician rated hallucinations and positive symptoms over widespread cortical regions. Our finding of diminished spindle activity and its association with hallucinations likely reflect dysfunction of the thalamocortical circuits in children and adolescents with COS. Given the relative ease of sleep EEG recordings in vulnerable populations, this study highlights the potential of such recordings to characterize brain function in schizophrenia.
Identifiants
pubmed: 32980206
pii: S0920-9964(20)30450-3
doi: 10.1016/j.schres.2020.08.022
pmc: PMC7704640
mid: NIHMS1636949
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT00049738']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-336Subventions
Organisme : NCRR NIH HHS
ID : P41 RR013642
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA MH002581
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to declare.
Références
Am J Psychiatry. 2003 Dec;160(12):2181-9
pubmed: 14638588
Front Hum Neurosci. 2014 Oct 07;8:762
pubmed: 25339881
Biol Psychiatry. 1986 Oct;21(12):1175-88
pubmed: 2875742
Am J Psychiatry. 2007 Mar;164(3):483-92
pubmed: 17329474
Perspect Biol Med. 1986 Spring;29(3 Pt 1):437-60
pubmed: 3714435
J Neurosci. 1993 Aug;13(8):3266-83
pubmed: 8340807
Nutr Rev. 2014 Oct;72 Suppl 1:60-4
pubmed: 25293544
Clin Electroencephalogr. 1999 Apr;30(2):39-43
pubmed: 10358781
Psychiatry Res Neuroimaging. 2018 Sep 30;279:40-50
pubmed: 29861197
J Neurosci. 2010 Oct 6;30(40):13211-9
pubmed: 20926647
J Child Psychol Psychiatry. 2006 Oct;47(10):1003-12
pubmed: 17073979
Biol Psychiatry. 2003 Feb 1;53(3):244-53
pubmed: 12559658
J Sleep Res. 2020 Apr 30;:e13039
pubmed: 32350968
Sleep. 2013 Feb 01;36(2):237-43
pubmed: 23372271
Schizophr Res. 2006 Sep;86(1-3):123-9
pubmed: 16730952
Neuroscience. 2006;137(4):1087-106
pubmed: 16343791
Nat Methods. 2014 Apr;11(4):385-92
pubmed: 24562424
Eur J Neurosci. 2018 Oct;48(8):2738-2758
pubmed: 29280209
Annu Rev Clin Psychol. 2013;9:555-87
pubmed: 23537488
J Psychiatr Res. 2010 Jan;44(2):112-20
pubmed: 19665729
Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):675-87
pubmed: 24012080
Biol Psychiatry. 1989 Jan;25(1):60-6
pubmed: 2563232
J Neurosci. 2018 Oct 24;38(43):9275-9285
pubmed: 30249805
Sleep Med. 2015 May;16(5):564-9
pubmed: 25912599
Am J Psychiatry. 2010 Nov;167(11):1339-48
pubmed: 20843876
Prog Neurobiol. 2005 Feb;75(2):125-41
pubmed: 15784303
J Clin Neurophysiol. 2015 Apr;32(2):159-63
pubmed: 25350635
Biol Psychiatry. 2016 Oct 15;80(8):599-608
pubmed: 26602589
Curr Psychiatry Rep. 2009 Apr;11(2):156-61
pubmed: 19302770
J Psychiatr Res. 1982-1983;17(4):319-34
pubmed: 7187776
Schizophr Res. 2017 Feb;180:36-43
pubmed: 27269670
Science. 1993 Jul 16;261(5119):361-4
pubmed: 8392750
J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):636-44
pubmed: 8056726
Biol Psychiatry. 1999 Nov 15;46(10):1418-28
pubmed: 10578456
Science. 2018 Feb 9;359(6376):693-697
pubmed: 29439242
Biol Psychiatry. 2012 Jan 15;71(2):154-61
pubmed: 21967958
Brain. 2002 Feb;125(Pt 2):373-83
pubmed: 11844737
Neuroscience. 2006;138(1):351-6
pubmed: 16388912
J Neurophysiol. 1996 Dec;76(6):4152-68
pubmed: 8985908
Sleep. 2010 Jun;33(6):801-9
pubmed: 20550021
Neuroreport. 2000 Jan 17;11(1):127-30
pubmed: 10683843
Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):539-55
pubmed: 24012072
Int J Dev Neurosci. 2011 May;29(3):251-8
pubmed: 20955775
Biol Psychiatry. 1992 Dec 1;32(11):1028-34
pubmed: 1467383
J Neurosci Methods. 2007 Aug 15;164(1):177-90
pubmed: 17517438
Schizophr Bull. 2008 Jan;34(1):30-6
pubmed: 17906336
Int J Psychophysiol. 2015 Jul;97(1):58-65
pubmed: 25958790
Schizophr Bull. 1994;20(4):697-712
pubmed: 7701277
Nat Neurosci. 2000 Oct;3(10):1027-34
pubmed: 11017176
Nat Commun. 2017 Jun 26;8:15930
pubmed: 28649997
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5177-80
pubmed: 19307577
NPJ Schizophr. 2018 Feb 9;4(1):2
pubmed: 29426848
Schizophr Bull. 2011 Mar;37(2):306-15
pubmed: 21131368
Nature. 2008 Nov 20;456(7220):391-4
pubmed: 18849967
Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10
pubmed: 11422885
Schizophr Res. 2015 Aug;166(1-3):355-7
pubmed: 25999041
Science. 1996 Nov 1;274(5288):771-4
pubmed: 8864114
Schizophr Res. 2016 Jun;173(3):124-131
pubmed: 25819937
Res Dev Disabil. 2013 Apr;34(4):1322-35
pubmed: 23417137
Psychol Bull. 1992 Jul;112(1):155-9
pubmed: 19565683
Schizophr Res. 2014 Mar;153(1-3):136-42
pubmed: 24485586
Arch Gen Psychiatry. 1996 Dec;53(12):1090-7
pubmed: 8956674