The biology of aggressive behavior in bipolar disorder: A systematic review.
Aggressive behavior
Biomarker
Bipolar disorder
Self-harm
Suicide
Violence
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
02
2020
revised:
26
08
2020
accepted:
08
09
2020
pubmed:
28
9
2020
medline:
22
6
2021
entrez:
27
9
2020
Statut:
ppublish
Résumé
Aggressive behavior (AB) represents a public health concern often associated with severe psychiatric disorders. Although most psychiatric patients are not aggressive, untreated psychiatric illness, including bipolar disorder (BD), may associate with an increased risk of AB. Accurate predictive models of AB are still lacking and it is crucial to delineate AB biomarkers state of the art in BD. We performed a systematic review according to PRISMA guidelines to identify biological correlates of AB in BD. Final results included 20 studies: 10 involving genetic and 10 other biological AB biomarkers (total sample size N = 5,181). Our results pointed to a serotoninergic hypoactivation in violent suicidal BD patients. Similarly, BD violent suicide attempters had a blunted hypothalamic-pituitary-adrenal (HPA) activity. Violent behavior in BD was associated with a chronic inflammatory state. While the role of lipids as biomarkers for AB remains equivocal, uric acid appears as a potential biomarker for hetero-AB in BD. Available data can be useful in the fulfill of specific biomarkers of AB in BD, ultimately leading to the development of accurate predictive models.
Identifiants
pubmed: 32980400
pii: S0149-7634(20)30572-8
doi: 10.1016/j.neubiorev.2020.09.015
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-20Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.