Sex Differences in Modifiable Risk Factors and Severity of Coronary Artery Disease.


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
20 10 2020
Historique:
pubmed: 29 9 2020
medline: 16 3 2021
entrez: 28 9 2020
Statut: ppublish

Résumé

Background It is still unknown whether traditional risk factors may have a sex-specific impact on coronary artery disease (CAD) burden. Methods and Results We identified 14 793 patients who underwent coronary angiography for acute coronary syndromes in the ISACS-TC (International Survey of Acute Coronary Syndromes in Transitional Countries; Clini​calTr​ials.gov, NCT01218776) registry from 2010 to 2019. The main outcome measure was the association between traditional risk factors and severity of CAD and its relationship with 30-day mortality. Relative risk (RR) ratios and 95% CIs were calculated from the ratio of the absolute risks of women versus men using inverse probability of weighting. Estimates were compared by test of interaction on the log scale. Severity of CAD was categorized as obstructive (≥50% stenosis) versus nonobstructive CAD. The RR ratio for obstructive CAD in women versus men among people without diabetes mellitus was 0.49 (95% CI, 0.41-0.60) and among those with diabetes mellitus was 0.89 (95% CI, 0.62-1.29), with an interaction by diabetes mellitus status of

Identifiants

pubmed: 32981423
doi: 10.1161/JAHA.120.017235
pmc: PMC7792418
doi:

Banques de données

ClinicalTrials.gov
['NCT01218776']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e017235

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Auteurs

Olivia Manfrini (O)

Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy.

Jinsung Yoon (J)

Department of Electrical and Computer Engineering University of California Los Angeles CA.

Mihaela van der Schaar (M)

Cambridge Centre for Artificial Intelligence in Medicine Department of Applied Mathematics and Theoretical Physics and Department of Population Health University of Cambridge Cambridge United Kingdom.

Sasko Kedev (S)

University Clinic of Cardiology Medical Faculty University "Ss. Cyril and Methodius" Skopje Macedonia.

Marija Vavlukis (M)

University Clinic of Cardiology Medical Faculty University "Ss. Cyril and Methodius" Skopje Macedonia.

Goran Stankovic (G)

Clinic of Cardiology University Clinical Centre of Serbia Belgrade Serbia.
Medical Faculty University of Belgrade Serbia.

Marialuisa Scarpone (M)

Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy.

Davor Miličić (D)

Department for Cardiovascular Diseases University Hospital Center Zagreb University of Zagreb Croatia.

Zorana Vasiljevic (Z)

Medical Faculty University of Belgrade Serbia.

Lina Badimon (L)

Cardiovascular Research Program ICCC, IR-IIBSant Pau, Hospital de la Santa Creu i Sant Pau, CiberCV-Institute Carlos III Barcelona Spain.

Edina Cenko (E)

Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy.

Raffaele Bugiardini (R)

Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy.

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Classifications MeSH